Carbapenem-resistant Gram-negative bacteria (CR-GNB) in ICUs: resistance genes, therapeutics, and prevention - a comprehensive review

被引：4

作者：

Li, Qi ^{[1
,2
]}

Zhou, Xiaoshi ^{[1
,2
]}

Yang, Rou ^{[1
,2
]}

Shen, Xiaoyan ^{[2
,3
]}

Li, Guolin ^{[1
,4
]}

Zhang, Changji ^{[1
,4
]}

Li, Pengfei ^{[2
]}

Li, Shiran ^{[1
,2
]}

Xie, Jingxian ^{[1
]}

Yang, Yong ^{[1
,2
]}

机构：

[1] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Sch Med, Dept Pharm, Chengdu, Peoples R China

[2] Univ Elect Sci & Technol China, Sch Med, Personalized Drug Therapy Key Lab Sichuan Prov, Chengdu, Peoples R China

[3] Chengdu Qingbaijiang Dist Peoples Hosp, Dept Pharm, Chengdu, Peoples R China

[4] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Nanjing, Peoples R China

来源：

FRONTIERS IN PUBLIC HEALTH | 2024年 / 12卷

关键词：

ICU; CR-GNB; mechanism; genes; infection control strategies; predictive model; BLOOD-STREAM INFECTION; INTENSIVE-CARE-UNIT; SPECTRUM BETA-LACTAMASES; CRITICALLY-ILL PATIENTS; IN-VITRO ACTIVITY; KLEBSIELLA-PNEUMONIAE; MULTIDRUG-RESISTANT; PSEUDOMONAS-AERUGINOSA; ANTIMICROBIAL RESISTANCE; CEFTAZIDIME-AVIBACTAM;

D O I：

10.3389/fpubh.2024.1376513

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Intensive care units (ICUs) are specialized environments dedicated to the management of critically ill patients, who are particularly susceptible to drug-resistant bacteria. Among these, carbapenem-resistant Gram-negative bacteria (CR-GNB) pose a significant threat endangering the lives of ICU patients. Carbapenemase production is a key resistance mechanism in CR-GNB, with the transfer of resistance genes contributing to the extensive emergence of antimicrobial resistance (AMR). CR-GNB infections are widespread in ICUs, highlighting an urgent need for prevention and control measures to reduce mortality rates associated with CR-GNB transmission or infection. This review provides an overview of key aspects surrounding CR-GNB within ICUs. We examine the mechanisms of bacterial drug resistance, the resistance genes that frequently occur with CR-GNB infections in ICU, and the therapeutic options against carbapenemase genotypes. Additionally, we highlight crucial preventive measures to impede the transmission and spread of CR-GNB within ICUs, along with reviewing the advances made in the field of clinical predictive modeling research, which hold excellent potential for practical application.

引用

页数：13

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