Controlled Molecular Arrangement of Cinnamic Acid in Layered Double Hydroxide through pi-pi Interaction for Controlled Release

被引:0
|
作者
Kim, Taeho [1 ]
Paek, Seung-Min [2 ]
Wang, Kang-Kyun [3 ]
Park, Jin Kuen [4 ]
Salles, Fabrice [5 ]
Oh, Jae-Min [1 ]
机构
[1] Dongguk Univ, Dept Energy & Mat Engn, Seoul 04620, South Korea
[2] Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea
[3] BI Biophoton Co Ltd, Gimpo 10090, South Korea
[4] Hankuk Univ Foreign Studies, Dept Chem, Yongin 17035, South Korea
[5] Univ Montpellier, Inst Charles Gerhardt ICGM, ENSCM, CNRS, F-34090 Montpellier, France
关键词
layered double hydroxide; molecular arrangement; phenolic acid; cinnamic acid; pi-pi interaction; release; intermolecular interaction; INTERCALATION; BEHAVIOR; DRUGS;
D O I
10.3390/ijms25084506
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cinnamic acid (CA) was successfully incorporated into Zn-Al layered double hydroxide (LDH) through coprecipitation. The CA moiety was stabilized in the interlayer space through not only electrostatic interaction but also intermolecular pi-pi interaction. It was noteworthy that the CA arrangement was fairly independent of the charge density of LDH, showing the important role of the layer-CA and CA-CA interactions in molecular stabilization. Computer simulations using the Monte Carlo method as well as analytical approaches including infrared, UV-vis spectroscopy, and differential scanning calorimetry showed the existence of intermolecular interaction. In order to reinforce molecular stabilization, a neutral derivative of CA, cinnamaldehyde (CAD), was additionally incorporated into LDH. It was clearly shown that CAD played a role as a pi-pi interaction mediator to enhance the stabilization of CA. The time-dependent release of CA from LDH was first governed by the layer charge density of LDH; however, the existence of CAD provided additional stabilization to the CA arrangement to slow down the release kinetics.
引用
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页数:15
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