Hyperatins A - D, highly oxidized polycyclic polyprenylated acylphloroglucinols from Hypericum perforatum L. with hypoglycemic potential in liver cells

被引：3

作者：

Guo, Yi ^{[1
]}

Xu, Qianqian ^{[2
]}

Tao, Bo ^{[1
]}

Huang, Xinye ^{[1
]}

Cao, Yunfang ^{[1
]}

Sun, Weiguang ^{[1
]}

Qi, Changxing ^{[1
]}

Zhu, Hucheng ^{[1
]}

Zhang, Yonghui ^{[1
]}

机构：

[1] Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Maternal & Child Hlth Hosp Hubei Prov, Tongji Med Coll, Wuhan 430030, Peoples R China

来源：

PHYTOCHEMISTRY | 2024年 / 221卷

基金：

中国国家自然科学基金;

关键词：

Hypericum perforatum L; Hypericaceae; Polycyclic polyprenylated acylphloroglucinols; Hypoglycemic activity; Glycogen synthase kinase 3; ST-JOHNS-WORT; HYPERFORIN; CONSTITUENTS; INHIBITION; DEPRESSION; METABOLISM; EXTRACTS;

D O I：

10.1016/j.phytochem.2024.114047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hyperatins A -D ( 1 - 4 ), four previously undescribed polycyclic polyprenylated acylphloroglucinols, were isolated from Hypericum perforatum L. (St. John 's wort). Compound 1 possessed a unique octahydroindeno[1,7a- b ]oxirene ring system with a rare 2,7-dioxabicyclo[2.2.1]heptane fragment. Compounds 2 - 4 had an uncommon decahydrospiro[furan-3,7 ' -indeno[7,1- bc ]furan] ring system. Their structures were established by spectroscopic analyses and X-ray crystallography. Plausible biosynthetic pathways of 1 - 4 were also proposed. Compounds 1 and 2 exerted promising hypoglycemic activity by inhibiting glycogen synthase kinase 3 expression in liver cells.

引用

页数：8

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