Sequence-Specific PI Polyamides Make It Possible to Regulate DNA Structure and Function

被引：11

作者：

Bando, Toshikazu ^{[1
]}

Sugiyama, Hiroshi ^{[1
,2
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan

[2] Kyoto Univ, Inst Integrated Cell Mat Sci WPI iCeMS, Sakyo Ku, Kyoto 6068501, Japan

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2020年 / 93卷 / 02期

关键词：

PI polyamides; Sequence-specific DNA binding; Regulation of gene expression; G-QUADRUPLEX INDUCTION; MINOR-GROOVE; TRANSCRIPTION; BINDING; RECOGNITION; MOLECULES; DESIGN; MIMICKING; PROMOTER; BIOLOGY;

D O I：

10.1246/bcsj.20190311

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As part of our research over the past 20 years, we have designed sequence-specific DNA-binding ligands that are based on the chemical molecular recognition of bases in nucleic acids. The DNA minor groove-binding molecules, N-methyl-pyrrole (P), and N-methylimidazole (I) polyamides, have been developed to regulate the specific gene expression or high-order DNA structures and visualize specific DNA sequences in cells. The binding properties of PI polyamides were designed to target specific sequences for various chemical applications. The development of PI polyamides may be useful when applying the vast base sequence information obtained from recent genomic-level research.

引用

页码：205 / 215

页数：11

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