Cardiovascular disease therapeutics via engineered oral microbiota: Applications and perspective

被引：65

作者：

Zhen, Wenyu ^{[1
]}

Wang, Zifei ^{[1
]}

Wang, Qing ^{[1
]}

Sun, Wansu ^{[2
]}

Wang, Rui ^{[1
]}

Zhang, Wenhao ^{[1
]}

Zhang, Yulong ^{[1
]}

Qin, Wengang ^{[3
]}

Li, Bang ^{[1
]}

Wang, Qingqing ^{[1
]}

Hong, Biao ^{[1
]}

Yang, Yicheng ^{[4
]}

Xu, Jing ^{[4
]}

Ma, Siyu ^{[5
]}

Da, Ming ^{[5
]}

Feng, Linfei ^{[2
]}

Zang, Xiaodong ^{[3
]}

Mo, Xuming ^{[5
]}

Sun, Xiaoyu ^{[1
]}

Wu, Mingyue ^{[1
]}

Xu, Junji ^{[6
]}

Xu, Jianguang ^{[1
]}

Huang, Yuan ^{[4
]}

Zhang, Hengguo ^{[1
]}

机构：

[1] Anhui Med Univ, Coll & Hosp Stomatol, Key Lab Oral Dis Res Anhui Prov, Hefei 230032, Peoples R China

[2] Anhui Med Univ, Dept Stomatol, Affiliated Hosp 1, Hefei, Peoples R China

[3] Univ Sci & Technol China, Affiliated Hosp USTC 1, Div Life Sci & Med, Hefei, Peoples R China

[4] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, State Key Lab Cardiovasc Dis, Natl Ctr Cardiovasc Dis,Pediat Cardiac Surg Ctr, Beijing, Peoples R China

[5] Nanjing Med Univ, Dept Cardiothorac Surg, Childrens Hosp, Nanjing, Peoples R China

[6] Capital Med Univ, Sch Stomatol, Dept Periodont, Lab Tissue Regenerat & Immunol,Beijing Key Lab Too, Beijing, Peoples R China

来源：

IMETA | 2024年 / 3卷 / 03期

基金：

中国国家自然科学基金;

关键词：

cardiovascular diseases; engineered microbiota; oral microbiota;

D O I：

10.1002/imt2.197

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Engineering bacteria are considered as a potential treatment for cardiovascular diseases and related risk factors. Oral bacteria are closely related to the occurrence and development of cardiovascular diseases, and their engineering has broad prospects and potential in the treatment of cardiovascular diseases. Oral pathogenic bacteria undergo protein and genetic engineering, including the incorporation of exogenous plasmids to yield therapeutic effects; genetically engineered oral probiotics can be harnessed to secrete cytokines and reactive oxygen species, offering novel therapeutic avenues for cardiovascular diseases. image

引用

页数：6

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