Long-term co-circulation of multiple influenza A viruses in pigs, Guangxi, China

被引:1
作者
Huang, Chongqiang [1 ,2 ,3 ]
Yu, Liangzheng [1 ]
Xu, Yi [1 ,2 ,3 ]
Huang, Jiamo [1 ,2 ,3 ]
Qin, Yibin [1 ,4 ]
Guo, Xuan [1 ,5 ]
Zeng, Yongfang [6 ]
Qin, Yifeng [1 ,2 ,3 ]
Ouyang, Kang [1 ,2 ,3 ]
Wei, Zuzhang [1 ,2 ,3 ]
Huang, Weijian [1 ,2 ,3 ]
Garcia-Sastre, Adolfo [7 ,8 ,9 ]
Chen, Ying [1 ,2 ,3 ]
机构
[1] Guangxi Univ, Coll Anim Sci & Technol, Lab Anim Infect Dis & Mol Immunol, Nanning, Peoples R China
[2] Guangxi Zhuang Autonomous Reg Engn Res Ctr Vet Bi, Nanning, Peoples R China
[3] Guangxi Key Lab Anim Breeding Dis Control & Preve, Nanning, Peoples R China
[4] Guangxi Inst Vet Med, Nanning, Peoples R China
[5] Guangxi Nongken Yongxin Anim Husb Grp Co Ltd, Nanning, Peoples R China
[6] Nanning Houxin Biotechnol Co Ltd, Nanning, Peoples R China
[7] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY USA
[8] Icahn Sch Med Mt Sinai, Global Hlth & Emerging Pathogens Inst, New York, NY USA
[9] Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, New York, NY USA
关键词
Swine influenza virus; multiple reassortment; pandemic potential; AVIAN-LIKE H1N1; EVOLUTIONARY GENOMICS; SWINE H1N1; ORIGIN; REASSORTMENT; GENES; HEMAGGLUTININ; TRANSMISSION; VIRULENCE; GENETICS;
D O I
10.1080/22221751.2024.2337673
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Influenza A viruses (IAVs) pose a persistent potential threat to human health because of the spillover from avian and swine infections. Extensive surveillance was performed in 12 cities of Guangxi, China, during 2018 and 2023. A total of 2540 samples (including 2353 nasal swabs and 187 lung tissues) were collected from 18 pig farms with outbreaks of respiratory disease. From these, 192 IAV-positive samples and 19 genomic sequences were obtained. We found that the H1 and H3 swine influenza A viruses (swIAVs) of multiple lineages and genotypes have continued to co-circulate during that time in this region. Genomic analysis revealed the Eurasian avian-like H1N1 swIAVs (G4) still remained predominant in pig populations. Strikingly, the novel multiple H3N2 genotypes were found to have been generated through the repeated introduction of the early H3N2 North American triple reassortant viruses (TR H3N2 lineage) that emerged in USA and Canada in 1998 and 2005, respectively. Notably, when the matrix gene segment derived from the H9N2 avian influenza virus was introduced into endemic swIAVs, this produced a novel quadruple reassortant H1N2 swIAV that could pose a potential risk for zoonotic infection.
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页数:12
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