Characterization of HIV-1 subtypes and drug resistance mutations in Slovakia: update 2017-2018

被引：0

作者：

Habekova, Monika ^{[1
]}

Stanekova, Danica Valkovicova ^{[1
]}

Takacova, Maria ^{[1
]}

Kovarova, Alexandra ^{[1
]}

机构：

[1] Slovak Med Univ, Natl Reference Ctr HIV AIDS Prevent, Limbova 14, SK-83301 Bratislava, Slovakia

来源：

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | 2024年 / 125卷 / 03期

关键词：

HIV-1; subtypes; Slovakia; resistance; ART; GENETIC DIVERSITY; TYPE-1; STRAINS; UKRAINE;

D O I：

10.4149/BLL_2024_26

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES: This study aimed to provide an overview on the HIV-1 subtypes circulating in Slovakia between 2017 and 2018 and to evaluate the risk of transmission of HIV-resistant strains. BACKGROUND: The HIV epidemic in Slovakia is characterised by low incidence of new and pre-existing infections and a slightly elevated level of strain heterogeneity. METHODS: Partial HIV pol gene sequences of 110 individuals newly diagnosed with HIV between 2017 and 2018 were analysed. RESULTS: The genotypic analysis revealed sporadic occurrence of mutations linked to HIV resistance to antiretroviral therapy (ART). The HIV-1 B subtype has been found as predominant (84.55 %) and primarily linked to men who have sex with men (MSM). A total of eighteen individuals (15.45 %) were found to be infected with HIV-1 non-B subtypes. CONCLUSION: The data suggest a minimal risk of a resistant HIV strain transmission and a marginal rise of HIV-1 subtypes ' diversity. The HIV-1 B subtype remains the most prevalent in the period 2017-2018 in Slovakia (Tab. 2, Fig. 2, Ref. 37). Text in PDF www.elis.sk

引用

页码：166 / 171

页数：6

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