Effect of sheep bone protein hydrolysate on promoting calcium absorption and enhancing bone quality in low-calcium diet fed rats

被引：11
作者：
Hu, Guanhua [1 ,2 ]
Sun, Xueying [1 ,2 ]
Hao, Shiqi [1 ,2 ]
Li, Xiaotong [1 ,2 ]
Qian, Min [1 ,2 ]
Dou, Lu [1 ,2 ]
Zhang, Min [1 ,2 ]
Hou, Puxin [3 ]
Su, Lin [1 ,2 ]
Zhao, Lihua [1 ,2 ]
Sun, Lina [1 ,2 ]
Jin, Ye [1 ,2 ]
机构：
[1] Inner Mongolia Agr Univ, Coll Food Sci & Engn, Hohhot 010018, Peoples R China
[2] Minist Agr & Rural Affairs Peoples Republ China, Integrat Res Base Beef & Lamb Proc Technol, Hohhot 010018, Peoples R China
[3] Sci & Technol Achievement Transformat Ctr, Bayan Nur 015000, Peoples R China
来源：
FOOD CHEMISTRY | 2024年 / 446卷
关键词：
Sheep bone protein hydrolysate; Low calcium diet; Calcium absorption; Bone health; Gut microbiota; CHELATING PEPTIDES; OSTEOPOROSIS; MICROARCHITECTURE; BIOAVAILABILITY; MECHANISMS; TURNOVER; HEALTH; FEMUR;
D O I：
10.1016/j.foodchem.2024.138763
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Calcium deficiency is prone to fractures, osteoporosis and other symptoms. In this study, sheep bone protein hydrolysates (SBPHs) were obtained by protease hydrolysis. A low-calcium-diet-induced calcium-deficiency rat model was established to investigate the effects of SBPHs on calcium absorption and intestinal flora composition. The results showed that an SBPHs + CaCl2 treatment significantly increased the bone calcium content, bone mineral density, trabecular bone volume, and trabecular thickness, and reduced trabecular separation, and changed the level of bone turnover markers (P < 0.05). Supplementation of SBPHs + CaCl2 can remarkably enhance the bone mechanical strength, and the microstructure of bone was improved, and the trabecular network was more continuous, complete, and thicker. Additionally, SBPHs + CaCl2 dietary increased the abundance of Firmicutes and reduced the abundance of Proteobacteria and Verrucomicrobiota, and promoted the production of short chain fatty acids. This study indicated that SBPHs promoted calcium absorption and could be applied to alleviate osteoporosis.
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页数：10
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