Effect of galactose-depleted and intact xyloglucan intake on glucose and lipid metabolism in diet-induced obese mice

This study investigated the effects of galactose-depleted xyloglucan derived from tamarind seed gum (GXG-TG) on glucose and lipid metabolism in diet-induced obese mice by comparison with intact xyloglucan (TG). Twentyfour male C57BL/6J mice were fed a high-fat diet containing 3 g/100 g of either GXG-TG or TG for 12 weeks. Reduction of postprandial glucose rise was observed in the TG group compared to the control, whereas the GXGTG group showed intermediate values. Serum cholesterol levels and hepatic mRNA expression of HMG-CoA reductase were significantly lower in the GXG-TG and TG groups compared to the control, while there was no increase in cecal short chain fatty acids in the GXG-TG or TG group. These results indicated that GXG-TG was converted to insoluble dietary fiber and maintained the serum cholesterol-lowering effect, although the blood glucose level-lowering effect was attenuated. TG, although moderately viscous, improved glucose tolerance and lipid metabolism in diet-induced obesity model mice.