Effects and mechanisms of polycyclic aromatic hydrocarbons in inflammatory skin diseases

被引：15

作者：

Jin, Hui ^{[1
,2
,3
,4
]}

Lin, Ziyuan ^{[1
,2
,3
,4
]}

Pang, Tianyi ^{[5
]}

Wu, Jingwen ^{[6
]}

Zhao, Cheng ^{[1
,2
,3
,4
]}

Zhang, Ying ^{[1
,2
,3
,4
,7
]}

Lei, Yu ^{[1
,2
,3
,4
]}

Li, Qilin ^{[1
,2
,3
,4
]}

Yao, Xu ^{[1
,2
,3
,4
]}

Zhao, Ming ^{[1
,2
,3
,4
]}

Lu, Qianjin ^{[1
,2
,3
,4
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Nanjing, Peoples R China

[2] Chinese Acad Med Sci, Key Lab Basic & Translat Res Immune Mediated Skin, Nanjing, Peoples R China

[3] Jiangsu Key Lab Mol Biol Skin Dis & STIs, Nanjing, Peoples R China

[4] Chinese Acad Med Sci Inst Dermatol, Res Unit Key Technol Immune Related Skin Dis Diag, Nanjing, Peoples R China

[5] Cent South Univ, Xiangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China

[6] Cent South Univ, Dept Dermatol, Hunan Key Lab Med Epigen, Xiangya Hosp 2, Changsha, Peoples R China

[7] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Peoples R China

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2024年 / 925卷

基金：

中国国家自然科学基金;

关键词：

Polycyclic aromatic hydrocarbons; Psoriasis; Atopic dermatitis; Lupus erythematosus; Acne; Environmental triggers; SYSTEMIC-LUPUS-ERYTHEMATOSUS; MAJOR POLYAROMATIC HYDROCARBON; AUTOIMMUNE RHEUMATIC-DISEASES; DIESEL EXHAUST PARTICLES; AIR-POLLUTION; DNA METHYLATION; PARTICULATE MATTER; ATOPIC-DERMATITIS; OXIDATIVE STRESS; CIGARETTE-SMOKING;

D O I：

10.1016/j.scitotenv.2024.171492

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Polycyclic aromatic hydrocarbons (PAHs) are hydrocarbons characterized by the presence of multiple benzene rings. They are ubiquitously found in the natural environment, especially in environmental pollutants, including atmospheric particulate matter, cigarette smoke, barbecue smoke, among others. PAHs can influence human health through several mechanisms, including the aryl hydrocarbon receptor (AhR) pathway, oxidative stress pathway, and epigenetic pathway. In recent years, the impact of PAHs on inflammatory skin diseases has garnered significant attention, yet many of their underlying mechanisms remain poorly understood. We conducted a comprehensive review of articles focusing on the link between PAHs and several inflammatory skin diseases, including psoriasis, atopic dermatitis, lupus erythematosus, and acne. This review summarizes the effects and mechanisms of PAHs in these diseases and discusses the prospects and potential therapeutic implications of PAHs for inflammatory skin diseases.

引用

页数：16

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