Purpose of ReviewThis review article highlights recent advancements in the treatment of non-melanoma skin cancer (NMSC), focusing on efficacy and safety considerations, in the elderly population. We explore the unique challenges faced by older adults, including comorbidities and age-related skin changes, and discuss how treatment is evolving to address these needs.Recent FindingsRecent research in NMSC treatment highlights a shift towards tailored approaches for older adults, considering factors such as frailty, functional status, and treatment tolerance. Both surgical and non-surgical modalities continue to evolve, with an emphasis on maximizing therapeutic benefits while minimizing adverse effects in this vulnerable population.SummaryThis review provides a comprehensive summary of developments in NMSC treatment, underscoring the importance of individualized care for older adults. By considering the challenges and characteristics of this demographic, clinicians can make informed decisions to optimize treatment outcomes and improve quality of life for elderly patients with NMSC.