Non-Melanoma Skin Cancer Treatment Updates in the Elderly

被引:0
作者
Myers, Emma L. [1 ]
Blasiak, Rachel C. [2 ]
机构
[1] Univ N Carolina, Sch Med, Chapel Hill, NC 27516 USA
[2] Univ N Carolina, Dept Dermatol, Chapel Hill, NC USA
关键词
Geriatric; Non-melanoma Skin Cancer; Oncology; Elderly Treatment Advances; Palliative Care; Novel Therapies; MOHS MICROGRAPHIC SURGERY; BASAL-CELL CARCINOMA; DERMATOLOGICAL SURGERY; SURGICAL-TREATMENT; LIFE EXPECTANCY; 5-FLUOROURACIL; PREVALENCE; MANAGEMENT; MELANOMA; EXCISION;
D O I
10.1007/s13670-024-00415-w
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Purpose of ReviewThis review article highlights recent advancements in the treatment of non-melanoma skin cancer (NMSC), focusing on efficacy and safety considerations, in the elderly population. We explore the unique challenges faced by older adults, including comorbidities and age-related skin changes, and discuss how treatment is evolving to address these needs.Recent FindingsRecent research in NMSC treatment highlights a shift towards tailored approaches for older adults, considering factors such as frailty, functional status, and treatment tolerance. Both surgical and non-surgical modalities continue to evolve, with an emphasis on maximizing therapeutic benefits while minimizing adverse effects in this vulnerable population.SummaryThis review provides a comprehensive summary of developments in NMSC treatment, underscoring the importance of individualized care for older adults. By considering the challenges and characteristics of this demographic, clinicians can make informed decisions to optimize treatment outcomes and improve quality of life for elderly patients with NMSC.
引用
收藏
页码:93 / 103
页数:11
相关论文
共 78 条
[1]   Pigmented Basal Cell Carcinoma Masquerading as a Melanoma [J].
Abudu, Boya ;
Cohen, Philip R. .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2019, 11 (04)
[2]   Dermatologic surgery in geriatric patients: Psychosocial considerations and perioperative decision-making [J].
Alam, M ;
Norman, RA ;
Goldberg, LH .
DERMATOLOGIC SURGERY, 2002, 28 (11) :1043-1050
[3]   Non-Melanoma Skin Cancers in the Older Patient [J].
Albert, Ashley ;
Knoll, Miriam A. ;
Conti, John A. ;
Zbar, Ross I. S. .
CURRENT ONCOLOGY REPORTS, 2019, 21 (09)
[4]   TREATMENT OF CUTANEOUS TUMORS WITH TOPICAL 5% IMIQUIMOD CREAM [J].
Alessi, Sabrina Sisto ;
Sanches, Jose Antonio ;
de Oliveira, Walmar Roncalli ;
Messina, Maria Cristina ;
de Almeida Pimentel, Eugenio Raul ;
Festa Neto, Cyro .
CLINICS, 2009, 64 (10) :961-966
[5]   Efficacy of Hedgehog Pathway Inhibitors in Basal Cell Carcinoma [J].
Basset-Seguin, Nicole ;
Sharpe, Hayley J. ;
de Sauvage, Frederic J. .
MOLECULAR CANCER THERAPEUTICS, 2015, 14 (03) :633-641
[6]   Phase I Study of LY2940680, a Smo Antagonist, in Patients with Advanced Cancer Including Treatment-Naive and Previously Treated Basal Cell Carcinoma [J].
Bendell, Johanna ;
Andre, Valerie ;
Ho, Alan ;
Kudchadkar, Ragini ;
Migden, Michael ;
Infante, Jeffrey ;
Tiu, Ramon V. ;
Pitou, Celine ;
Tucker, Trevor ;
Brail, Les ;
Von Hoff, Daniel .
CLINICAL CANCER RESEARCH, 2018, 24 (09) :2082-2091
[7]   The State of the Art of Radiotherapy for Non-melanoma Skin Cancer: A Review of the Literature [J].
Benkhaled, Sofian ;
Van Gestel, Dirk ;
Gomes da Silveira Cauduro, Carolina ;
Palumbo, Samuel ;
del Marmol, Veronique ;
Desmet, Antoine .
FRONTIERS IN MEDICINE, 2022, 9
[8]  
Bittner GC, 2021, AN BRAS DERMATOL, V96, P263
[9]   Sonidegib for the Treatment of Advanced Basal Cell Carcinoma [J].
Brancaccio, Gabriella ;
Pea, Federico ;
Moscarella, Elvira ;
Argenziano, Giuseppe .
FRONTIERS IN ONCOLOGY, 2020, 10
[10]   SURGICAL MARGINS FOR EXCISION OF PRIMARY CUTANEOUS SQUAMOUS-CELL CARCINOMA [J].
BRODLAND, DG ;
ZITELLI, JA .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1992, 27 (02) :241-248