Attenuation effect of a polysaccharide from large leaf yellow tea by activating autophagy

被引：3

作者：

Chen, Hao ^{[1
]}

Wang, Zhuang ^{[1
]}

Gong, Lei ^{[1
]}

Chen, Jielin ^{[1
]}

Huang, Yuzhe ^{[1
]}

Guo, Wenqiang ^{[1
]}

Zhang, Qiang ^{[1
]}

Li, Yong ^{[1
]}

Bao, Guanhu ^{[2
]}

Li, Daxiang ^{[2
]}

Chen, Yan ^{[1
,3
]}

机构：

[1] Anhui Univ, Sch Life Sci, Anhui Key Lab Ecol Engn & Biotechnol, Hefei 230601, Anhui, Peoples R China

[2] Anhui Agr Univ, Sch Tea & Food Sci Technol, State Key Lab Tea Plant Biol & Utilizat, 130 Changjiang Rd West, Hefei 230036, Anhui, Peoples R China

[3] Anhui Univ, Sch Life Sci, 111 Jiulong Rd, Hefei 230601, Anhui, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 265卷

关键词：

Attenuation; Autophagy; Gut microbiota; Anti-tumour; Large-leaf yellow tea polysaccharides; TOXICITY; 5-FU;

D O I：

10.1016/j.ijbiomac.2024.130697

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemotherapy, the most common class of anticancer drugs, is considerably limited owing to its adverse side effects. In this study, we aimed to evaluate the protective effect and mechanism of action of large-leaf yellow tea polysaccharides (ULYTP-1, 1.29 x 104 Da) against chemotherapeutic 5-fluorouracil (5-Fu). Structural characterisation revealed that ULYTP-1 was a beta-galactopyranouronic acid. Furthermore, ULYTP-1 promoted autolysosome formation, activating autophagy and reducing the oxidative stress and inflammation caused by 5-Fu. Our in vivo study of 4 T1 tumour-bearing mice revealed that ULYTP-1 also attenuated 5-Fu toxicity through modulation of the gut microbiota. Moreover, ULYTP-1 effectively protected immune organs and the liver from 5-Fu toxicity, while promoting its tumour-inhibitory properties. The current findings provide a new strategy for optimising chemotherapy regimens in the clinic.

引用

页数：10

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[1] Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-KB/JNK signaling pathway in aging mouse model [J].