Emerging frontiers in androgen receptor research for prostate Cancer: insights from the 2nd international androgen receptor Symposium

被引:1
|
作者
Israel, Justus Simon [1 ]
Marcelin, Laura-Maria [1 ]
Thomas, Christian [1 ]
Szczyrbova, Eva [2 ,3 ]
Fuessel, Susanne [1 ,4 ,5 ]
Puhr, Martin [6 ]
Linxweiler, Johannes [7 ]
Yalala, Shivani [8 ]
Zwart, Wilbert T. [9 ]
Baniahmad, Aria [10 ]
van Goubergen, Jasper [6 ]
Itkonen, Harri M. [8 ]
Sharp, Adam [11 ]
O'Neill, Edward [12 ]
Pretze, Marc [13 ]
Miederer, Matthias [14 ,15 ,16 ,17 ]
Erb, Holger H. H. [1 ,10 ,18 ]
机构
[1] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Fac Med, Dept Urol, Dresden, Germany
[2] Palacky Univ, Inst Mol & Translat Med, Fac Med & Dent, Dept Clin & Mol Pathol, Olomouc 77900, Czech Republic
[3] Univ Hosp, Olomouc 77900, Czech Republic
[4] German Canc Consortium DKTK, Partner Site Dresden, Heidelberg, Germany
[5] German Canc Res Ctr, Heidelberg, Germany
[6] Med Univ Innsbruck, Dept Urol, Innsbruck, Austria
[7] Saarland Univ, Dept Urol, Homburg, Germany
[8] Univ Helsinki, Fac Med, Dept Biochem & Dev Biol, Helsinki, Finland
[9] Netherlands Canc Inst, Oncode Inst, Div Oncogen, Amsterdam, Netherlands
[10] Friedrich Schiller Univ, Jena Univ Hosp, Inst Human Genet, Jena, Germany
[11] Inst Canc Res, Sutton, Surrey, England
[12] Univ Oxford, MRC Oxford Inst Radiat Oncol, Dept Oncol, Oxford, England
[13] Helmholtz Zentrum Dresden Rossendorf, Inst Radiopharm, Bautzner Landstr 400, D-01328 Dresden, Germany
[14] Natl Ctr Tumor Dis NCT UCC Dresden, Dept Translat Imaging Oncol, Dresden, Germany
[15] Univ Technol Dresden TUD, Fac Med, German Canc Res Ctr DKFZ Heidelberg, Dresden, Germany
[16] Univ Technol Dresden TUD, Univ Hosp Carl Gustav Carus, German Canc Res Ctr DKFZ Heidelberg, Dresden, Germany
[17] Helmholtz Zent Dresden Rossendorf HZDR, Dresden, Germany
[18] Tech Univ Dresden, Univ klinikum Carl Gustav Carus, Fetscherstr 74, D-01307 Dresden, Germany
关键词
AR; PCa; Androgen deprivation therapy; PSMA; DEPENDENT KINASE INHIBITOR; GLUCOCORTICOID-RECEPTOR; PHASE-I; DNA-DAMAGE; OPEN-LABEL; CASTRATION; ENZALUTAMIDE; RESISTANCE; MECHANISMS; THERAPY;
D O I
10.1186/s13046-024-03125-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Continued exploration of the androgen receptor (AR) is crucial, as it plays pivotal roles in diverse diseases such as prostate cancer (PCa), serving as a significant therapeutic focus. Therefore, the Department of Urology Dresden hosted an international meeting for scientists and clinical oncologists to discuss the newest advances in AR research. The 2nd International Androgen Receptor Symposium was held in Dresden, Saxony, Germany, from 26-27.04.2024, organised by Dr. Holger H.H. Erb. Following the format of the first meeting, more than 35 scientists from 8 countries attended the event to discuss recent developments, research challenges, and identification of venues in AR research. An important new feature was the involvement of PhD students and young investigators, acknowledging the high scientific quality of their work. The symposium included three covers: new advances from clinical research, basic and translational research, and novel strategies to target AR. Moreover, based on its increasing clinical relevance, a PSMA theranostic mini-symposium was added at the end of the AR symposium to allow the audience to discuss the newest advances in PSMA theranostic. This report focuses on the highlights and discussions of the meeting.
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页数:14
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