Detection of Mycobacterium tuberculosis and rifampicin resistance by Xpert® MTB/RIF assay among presumptive tuberculosis patients in Addis Ababa, Ethiopia from 2014 to 2021

被引：6

作者：

Diriba, Getu ^{[1
,6
,7
]}

Alemu, Ayinalem ^{[1
]}

Tola, Habteyes Hailu ^{[2
]}

Eshetu, Kirubel ^{[3
]}

Yenew, Bazezew ^{[1
]}

Amare, Misikir ^{[1
]}

Dagne, Biniyam ^{[1
]}

Mollalign, Hilina ^{[1
]}

Sinshaw, Waganeh ^{[1
]}

Abebaw, Yeshiwork ^{[1
]}

Seid, Getachew ^{[1
]}

Tadesse, Mengistu ^{[1
]}

Zerihun, Betselot ^{[1
]}

Getu, Melak ^{[1
]}

Moga, Shewki ^{[1
]}

Meaza, Abyot ^{[1
]}

Gamtesa, Dinka Fekadu ^{[1
]}

Tefera, Zigba ^{[1
]}

Wondimu, Amanuel ^{[1
]}

Hailu, Michael ^{[1
]}

Buta, Bedo ^{[1
]}

Getahun, Muluwork ^{[1
]}

Kebede, Abebaw ^{[4
,5
]}

机构：

[1] Ethiopian Publ Hlth Inst, Natl TB Reference Lab, Addis Ababa, Ethiopia

[2] Addis Ababa Univ, Aklilu Lemma Inst Pathobiol, Addis Ababa, Ethiopia

[3] Selale Univ, Coll Hlth Sci, Dept Publ Hlth, Fiche, Ethiopia

[4] USAID Eliminate TB Project, Management Sci Hlth, Addis Ababa, Ethiopia

[5] Addis Ababa Univ, Coll Nat & Computat Sci, Dept Microbial Cellular & Mol Biol, Addis Ababa, Ethiopia

[6] Africa Ctr Dis Control & Prevent, Addis Ababa, Ethiopia

[7] Publ Hlth Inst, POB 1242, Addis Ababa, Ethiopia

来源：

IJID REGIONS | 2022年 / 5卷

关键词：

Xpert MTB/RIF; Mycobacterium tuberculosis; rifampicin resistance; frequency; GENEXPERT MTB/RIF; PREVALENCE;

D O I：

10.1016/j.ijregi.2022.09.001

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objective: This study aimed to determine the frequencies and trends of Mycobacterium tuberculosis and rifampicin resistance among presumptive tuberculosis patients in Ethiopia, who were tested using the Xpert MTB/RIF assay between 2014 and 2021.Methods: Data were collected retrospectively from patient registries. Laboratory-based data were extracted from the national tuberculosis (TB) referral laboratory database. All patients referred to the National Tuberculosis Reference Laboratory (NTRL) for TB diagnosis from all over the country between March 1, 2014 and September 30, 2021, and tested using the Xpert MTB/RIF assay, were included. The extracted data were entered into a Microsoft Excel sheet and analyzed by Statistical Package for Social Sciences (SPSS) version 23. Results: Among a total of 13 772 individuals tested using the Xpert MTB/RIF assay, the majority (8223; 59.7%) were males, and 48.5% (6678) of the individuals were aged between 15 and 39 years. Mycobacterium tuberculosis (MTB) was detected in 17.0% (2347) of the examined individuals. Of the detected MTB cases, nearly 9.9% (233) were rifampicin resistant (RR-TB), while 24 (1.0%) were RR-intermediate. Among all RR-TB cases, more than half (125; 53.6%) were detected in males, and 105 were new TB cases. Extrapulmonary (EPTB) patients had a greater rate of rifampicin resistance (11.0%) than pulmonary (PTB) patients (9.6%).Conclusion: The frequency of TB and RR-TB remains high in the study setting. RR-TB was found to have a statistically significant association with previous anti-TB medication treatment. As a result, improving treatment adherence in recognized instances could assist in preventing MTB and RR-TB cases.

引用

页码：97 / 103

页数：7

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