Pharmacological pain management in cancer patients

被引：0

作者：

Muetherig, Anke ^{[1
,2
]}

Scheffler, Gesine ^{[3
]}

Schuler, Ulrich S. ^{[1
,2
,4
]}

机构：

[1] Univ Klinikum Carl Gustav Carus Dresden, Palliativ Zentrum, Dresden, Germany

[2] Univ Klinikum Carl Gustav Carus Dresden, Med Klin & Poliklin 1, Dresden, Germany

[3] Univ Klinikum Carl Gustav Carus Dresden, Klin Apotheke, Dresden, Germany

[4] Univ Klinikum Carl Gustav Carus Dresden, Palliativ Zentrum, Fetscherstr 74, D-01307 Dresden, Germany

来源：

UROLOGIE | 2024年 / 63卷 / 05期

关键词：

Cancer pain; Analgesics; opioid; Morphine; Acetaminophen; Cannabinoids; ANALGESIC LADDER; MORPHINE; VALIDATION; METHADONE; EFFICACY; OPIOIDS; TRIAL;

D O I：

10.1007/s00120-024-02347-x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Pharmacological pain therapy in cancer patients is based on guideline recommendations, which, however, do not fully coincide in all aspects due to varying weighting of evidence. The present article discusses current issues including the decreasing significance of the World Health Organization (WHO) analgesic ladder, with its distinction between step 2 and 3 being increasingly questioned. Risks of nonopioid analgesics such as paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs), particularly in older populations, are discussed. Paracetamol may potentially reduce the effectiveness of immunotherapies. Aspects of administering analgesics via a feeding tube are considered. Recommendations for the treatment of episodic pain, transitioning between different opioids, and some relevant interactions are also discussed.

引用

页码：497 / 506

页数：10

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