The Role of Obesity and Inflammation in Breast Cancer Recurrence

被引：0
作者：
Chew, Sonya M. [1 ]
Liu, Bethina [2 ,3 ]
Shen, Sherry [2 ,3 ]
Iyengar, Neil M. [2 ,3 ]
机构：
[1] Univ Galway Hosp, Med Oncol Serv, Galway, Ireland
[2] Evelyn H Lauder Breast Ctr, Mem Sloan Kettering Canc Ctr, Dept Med, Breast Med Serv, 300 East 66Th St,Off 823, New York, NY 10065 USA
[3] New York Presbyterian Weill Cornell Med, Dept Med, New York, NY 10065 USA
来源：
CURRENT BREAST CANCER REPORTS | 2024年 / 16卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Breast cancer; Inflammation; Obesity; Recurrence; Survivorship; BODY-MASS INDEX; WEIGHT-LOSS INTERVENTION; POSTMENOPAUSAL WOMEN; ENDOCRINE THERAPY; AMERICAN SOCIETY; RANDOMIZED-TRIAL; FAT DISTRIBUTION; LIFE-STYLE; RISK; OVERWEIGHT;
D O I：
10.1007/s12609-024-00550-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose of reviewThe purpose of this study is to summarize the latest findings regarding the impact of obesity and inflammation on breast cancer recurrence risk.Recent FindingsObesity is a risk factor for breast cancer recurrence and cancer-specific mortality. Biologic mechanisms that drive this association vary by tumor subtype and include a dysfunctional tumor microenvironment and systemic inflammation. We discuss the impact of obesity on systemic therapy resistance and review current evidence supporting pharmacological, surgical, and lifestyle modifications for addressing obesity in the context of improving breast cancer survivorship.SummaryObesity is associated with poorer survival in breast cancer. Risk stratification by tumor and host-specific characteristics can help identify adjunctive interventions to improve breast cancer outcomes in patients with obesity.
引用
收藏
页码：237 / 250
页数：14
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