The Role of Obesity and Inflammation in Breast Cancer Recurrence

被引：0
作者：
Chew, Sonya M. [1 ]
Liu, Bethina [2 ,3 ]
Shen, Sherry [2 ,3 ]
Iyengar, Neil M. [2 ,3 ]
机构：
[1] Univ Galway Hosp, Med Oncol Serv, Galway, Ireland
[2] Evelyn H Lauder Breast Ctr, Mem Sloan Kettering Canc Ctr, Dept Med, Breast Med Serv, 300 East 66Th St,Off 823, New York, NY 10065 USA
[3] New York Presbyterian Weill Cornell Med, Dept Med, New York, NY 10065 USA
来源：
CURRENT BREAST CANCER REPORTS | 2024年 / 16卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Breast cancer; Inflammation; Obesity; Recurrence; Survivorship; BODY-MASS INDEX; WEIGHT-LOSS INTERVENTION; POSTMENOPAUSAL WOMEN; ENDOCRINE THERAPY; AMERICAN SOCIETY; RANDOMIZED-TRIAL; FAT DISTRIBUTION; LIFE-STYLE; RISK; OVERWEIGHT;
D O I：
10.1007/s12609-024-00550-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose of reviewThe purpose of this study is to summarize the latest findings regarding the impact of obesity and inflammation on breast cancer recurrence risk.Recent FindingsObesity is a risk factor for breast cancer recurrence and cancer-specific mortality. Biologic mechanisms that drive this association vary by tumor subtype and include a dysfunctional tumor microenvironment and systemic inflammation. We discuss the impact of obesity on systemic therapy resistance and review current evidence supporting pharmacological, surgical, and lifestyle modifications for addressing obesity in the context of improving breast cancer survivorship.SummaryObesity is associated with poorer survival in breast cancer. Risk stratification by tumor and host-specific characteristics can help identify adjunctive interventions to improve breast cancer outcomes in patients with obesity.
引用
收藏
页码：237 / 250
页数：14
相关论文
共 109 条
  • [1] Obesity is associated with early recurrence on breast cancer patients that achieved pathological complete response to neoadjuvant chemotherapy
    Acevedo, Francisco
    Walbaum, Benjamin
    Muniz, Sabrina
    Petric, Militza
    Martinez, Raul
    Guerra, Constanza
    Navarro, Marisel
    Cordova-Delgado, Miguel
    Pinto, Mauricio P.
    Sanchez, Cesar
    [J]. SCIENTIFIC REPORTS, 2022, 12 (01)
  • [2] Association of Bariatric Surgery With Cancer Risk and Mortality in Adults With Obesity
    Aminian, Ali
    Wilson, Rickesha
    Al-Kurd, Abbas
    Tu, Chao
    Milinovich, Alex
    Kroh, Matthew
    Rosenthal, Raul J.
    Brethauer, Stacy A.
    Schauer, Philip R.
    Kattan, Michael W.
    Brown, Justin C.
    Berger, Nathan A.
    Abraham, Jame
    Nissen, Steven E.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2022, 327 (24): : 2423 - 2433
  • [3] [Anonymous], Overweight obesity statistics
  • [4] The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank
    Arthur, Rhonda S.
    Dannenberg, Andrew J.
    Kim, Mimi
    Rohan, Thomas E.
    [J]. BRITISH JOURNAL OF CANCER, 2021, 124 (09) : 1592 - 1605
  • [5] Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies
    Aune, Dagfinn
    Keum, NaNa
    Giovannucci, Edward
    Fadnes, Lars T.
    Boffetta, Paolo
    Greenwood, Darren C.
    Tonstad, Serena
    Vatten, Lars J.
    Riboli, Elio
    Norat, Teresa
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2016, 353
  • [6] Body Mass Index and Treatment Outcomes in Metastatic Breast Cancer Patients Treated With Eribulin
    Barba, Maddalena
    Pizzuti, Laura
    Sperduti, Isabella
    Natoli, Clara
    Gamucci, Teresa
    Sergi, Domenico
    Di Lauro, Luigi
    Moscetti, Luca
    Izzo, Fiorentino
    Rinaldi, Massimo
    Mentuccia, Lucia
    Vaccaro, Angela
    Iezzi, Laura
    Grassadonia, Antonino
    Michelotti, Andrea
    Landucci, Elisabetta
    Perracchio, Letizia
    Pescarmona, Edoardo
    Di Filippo, Franco
    Giordano, Antonio
    Maugeri-Sacca, Marcello
    Vici, Patrizia
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2016, 231 (05) : 986 - 991
  • [7] Metabolomic profiles of metformin in breast cancer survivors: a pooled analysis of plasmas from two randomized placebo-controlled trials
    Bellerba, Federica
    Chatziioannou, Anastasia Chrysovalantou
    Jasbi, Paniz
    Robinot, Nivonirina
    Keski-Rahkonen, Pekka
    Trolat, Amarine
    Vozar, Beatrice
    Hartman, Sheri J.
    Scalbert, Augustin
    Bonanni, Bernardo
    Johansson, Harriet
    Sears, Dorothy D.
    Gandini, Sara
    [J]. JOURNAL OF TRANSLATIONAL MEDICINE, 2022, 20 (01)
  • [8] Obesity and metabolic syndrome are associated with short-term endocrine therapy resistance in early ER plus breast cancer
    Bergman, Riley
    Berko, Yvonne A.
    Sanchez, Violeta
    Sanders, Melinda E.
    Gonzalez-Ericsson, Paula, I
    Arteaga, Carlos L.
    Rexer, Brent N.
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2023, 197 (02) : 307 - 317
  • [9] Obese Adipose Tissue as a Driver of Breast Cancer Growth and Development: Update and Emerging Evidence
    Bhardwaj, Priya
    Brown, Kristy A.
    [J]. FRONTIERS IN ONCOLOGY, 2021, 11
  • [10] Obesity and survival among a cohort of breast cancer patients is partially mediated by tumor characteristics
    Blair, Cindy K.
    Wiggins, Charles L.
    Nibbe, Andrea M.
    Storlie, Curt B.
    Prossnitz, Eric R.
    Royce, Melanie
    Lomo, Lesley C.
    Hill, Deirdre A.
    [J]. NPJ BREAST CANCER, 2019, 5 (1)
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