Comparison of mechanochemical methods in the synthesis of binaphthol-benzoquinone based cocrystals

被引:2
|
作者
Nagapudi, Siddarth [1 ]
Nagapudi, Karthik [2 ]
机构
[1] Dougherty Valley High Sch, San Ramon, CA 94582 USA
[2] Genentech Inc, One DNA Way, South San Francisco, CA 94080 USA
关键词
TWIN-SCREW EXTRUSION; ACID COCRYSTAL; SCALE-UP; CRYSTALS; MANUFACTURE; STABILITY; IMPROVE;
D O I
10.1039/d3cp04713j
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Mechanochemical methods either under neat or liquid assisted conditions have proven to be successful in making cocrystals. In this paper we compare the outcome of cocrystallization using two different mechanochemical methods, ball milling (BM) and resonant acoustic mixing (RAM), with solution crystallization. Racemic binaphthol and benzoquinone based binary and ternary cocrystals were investigated by BM and RAM. Both mechanochemical methods were successful in making the binary and ternary cocrystals that have been observed in solid state and solution. It is shown that the type of mechanochemical force imparted to the sample is very different between BM and RAM and this in turn leads to different cocrystallization outcomes. Thus, different mechanochemical methods should not be treated as the same and care must be taken when choosing a mechanochemical method for a particular application. Mechanochemical methods either under neat or liquid assisted conditions have proven to be successful in making the cocrystals with different stoichiometries.
引用
收藏
页码:12545 / 12551
页数:7
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