Detection of enterovirus D68 among children with severe acute respiratory infection in Myanmar

被引：3

作者：

Ikuse, Tatsuki ^{[1
]}

Aizawa, Yuta ^{[1
]}

Kachikawa, Ryotaro ^{[1
]}

Kamata, Kazuhiro ^{[1
,2
]}

Osada, Hidekazu ^{[2
]}

Win, Su Mon Kyaw ^{[2
]}

Di Ja, Lasham ^{[2
]}

Win, Nay Chi ^{[2
]}

Thein, Khin Nyo ^{[3
]}

Thida, Aye ^{[4
]}

Tun, Aye ^{[5
]}

Ito, Ai ^{[1
]}

Kyaw, Yadanar ^{[3
]}

Tin, Htay Htay ^{[6
]}

Shobugawa, Yugo ^{[7
]}

Watanabe, Hisami ^{[7
]}

Saito, Reiko ^{[7
]}

Saitoh, Akihiko ^{[1
]}

机构：

[1] Niigata Univ, Grad Sch Med & Dent Sci, Dept Pediat, 1-754 Asahimachi Dori,Chuo Ku, Niigata, Japan

[2] Niigata Univ Myanmar, Infect Dis Res Ctr, 35 Maw Koon Tike St,Pyay East Ward, Yangon, Myanmar

[3] Yankin Children Hosp, 90 Thitsar Rd, Yangon, Myanmar

[4] Univ Med 2, Khaymar Thi Rd, Yangon, Myanmar

[5] Minist Hlth, Off 4, Nay Pyi Taw, Myanmar

[6] Univ Med Technol, Yangon Yangon Div, Insein Township, Myanmar

[7] Niigata Univ, Grad Sch Med & Dent Sci, Div Int Hlth, 1-754 Asahimachi Dori,Chuo Ku, Niigata, Japan

来源：

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION | 2024年 / 57卷 / 02期

关键词：

Myanmar; Outbreak; Severe acute; Children; OUTBREAK; SURVEILLANCE; CIRCULATION; EMERGENCE; ILLNESS; CLADE; B3;

D O I：

10.1016/j.jmii.2024.01.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Enterovirus D68 (EV-D68) is an important reemerging pathogen that causes severe acute respiratory infection and acute flaccid paralysis, mainly in children. Since 2014, EV-D68 outbreaks have been reported in the United States, Europe, and east Asia; however, no outbreaks have been reported in southeast Asian countries, including Myanmar, during the previous 10 years. Methods: EV-D68 was detected in nasopharyngeal swabs from children with acute lower respiratory infections in Myanmar. The samples were previously collected from children aged 1 month to 12 years who had been admitted to the Yankin Children Hospital in Yangon, Myanmar, between May 2017 and January 2019. EV-D68 was detected with a newly developed EV-D68 -specific real-time PCR assay. The clade was identified by using a phylogenetic tree created with the Bayesian Markov chain Monte Carlo method. Results: During the study period, nasopharyngeal samples were collected from 570 patients. EV-D68 was detected in 42 samples (7.4 %)-11 samples from 2017 to 31 samples from 2018. The phylogenetic tree revealed that all strains belonged to clade B3, which has been the domi- nant clade worldwide since 2014. We estimate that ancestors of currently circulating geno- types emerged during the period 1980-2004. Conclusions: To our knowledge, this is the first report of EV-D68 detection in children with acute lower respiratory infections in Yangon, Myanmar, in 2017-2018. Detection and detailed virologic analyses of EV-D68 in southeast Asia is an important aspect of worldwide surveillance and will likely be useful in better understanding the worldwide epidemiologic profile of EV-D68 infection. Copyright <feminine ordinal indicator> 2024, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/).

引用

页码：238 / 245

页数：8

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