Recent progress and prospects in the organocatalytic Morita-Baylis-Hillman reaction

被引：2

作者：

Maneesha, Mohammed ^{[1
]}

Haritha, S. H. ^{[2
]}

Aneeja, Thaipparambil ^{[1
]}

Anilkumar, Gopinathan ^{[1
,3
]}

机构：

[1] Mahatma Gandhi Univ, Sch Chem Sci, Priyadarsini Hills P O, Kottayam 686560, Kerala, India

[2] Sree Narayana Coll, Postgrad Dept Chem, Thiruvananthapuram 695145, Kerala, India

[3] Mahatma Gandhi Univ, Inst Integrated Programmes & Res Basic Sci IIRBS, Priyadarsini Hills P O, Kottayam 686560, Kerala, India

来源：

RSC ADVANCES | 2024年 / 14卷 / 21期

关键词：

Carbon - Rate constants - Unsaturated compounds;

D O I：

10.1039/d4ra02369b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The organocatalytic asymmetric Morita-Baylis-Hillman (MBH) reaction produces a significant carbon-carbon bond formation that involves the addition of alpha,beta-unsaturated carbonyl compounds to activated alkenes to give alpha-methylene-beta-hydroxycarbonyl compounds. Commercially available starting materials, excellent atom economy, mild reaction conditions, and flexible products are the major highlights of this method. In this review, we discuss the recent developments in the organocatalytic MBH reaction, covering literature from 2018 to 2023. The organocatalytic Morita-Baylis-Hillman (MBH) reaction, one of the most significant carbon-carbon bond formations involves the addition of alpha,beta-unsaturated carbonyl compounds to activated alkenes to give alpha-methylene-beta-hydroxycarbonyl compounds.

引用

页码：14949 / 14963

页数：15

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