Cinnamaldehyde Regulates the Migration and Apoptosis of Gastric Cancer Cells by Inhibiting the Jak2/Stat3 Pathway

被引：0
作者：
Geng, Yuan-yuan [1 ]
Yang, Shuo [2 ]
Liu, Zhi-hao [3 ]
Wang, Si-yu [3 ]
Ge, Pan [4 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Pathol, Xian 710004, Shaanxi, Peoples R China
[2] Huang Gang Hosp Tradit Chinese Med, Dept Cent Lab, Huanggang 438000, Hubei, Peoples R China
[3] Xi An Jiao Tong Univ, Med Sch, Xian 710061, Shaanxi, Peoples R China
[4] Xi An Jiao Tong Univ, Dept Pathol, Xian 710061, Shaanxi, Peoples R China
来源：
DIGESTIVE DISEASES AND SCIENCES | 2024年 / 69卷 / 08期
关键词：
Cinnamaldehyde; Jak2; Stat3; Gastric cancer;
D O I：
10.1007/s10620-024-08519-1
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
ObjectiveGastric cancer is a malignant tumor with high morbidity and mortality all around the world. Because of its poor prognosis and low survival rate, the treatment of gastric cancer has received extensive attention. Cinnamaldehyde (CA) is the main single active component of the Chinese herbal medicine cinnamon, which has a variety of pharmacological effects. The inhibitory effect of CA on the growth of some tumor cells has been proven, but its therapeutic effect on gastric cancer has rarely been reported.MethodsThrough network pharmacology, bioinformatics methods, and molecular docking technology, we predicted the interaction targets of CA and gastric cancer. Moreover, we found that apoptosis is an important mode of action of CA on gastric cancer cells. Subsequently, we validated it in gastric cancer cell lines cultured in vitro.ResultsThe results showed that in the presence of CA, the Jak2/Stat3 pathway was inhibited, the ratio of Bcl-2/Bax decreased, and the apoptosis of gastric cancer cells was promoted in a concentration-dependent.ConclusionIn conclusion, CA can promote the apoptosis of gastric cancer cells by inhibiting the activity of the Jak2/Stat3 pathway, which may achieve the effect of treating gastric cancer.
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页码：2875 / 2882
页数：8
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