Recently, printing electronic has attracted wide attention for its low cost, low energy consumption and simple process, which shows promising application prospect in microelectronics manufacturing. Inkjet printing is one of the most important methods of printing electronics allowing editing patterns through computer programming, which has always been a hot pot of research for its high speed and flexibility compared with vacuum process. During inkjet printing, deposition of ink on substrate involves interfacial wetting between ink and nozzle and between ink and substrate so that wetting can significantly affect graphing and function of printing patterns. From the aspect of interface, wetting in inkjet printing mainly refers to wetting between ink and substrate; from the aspect of surface, wettabilities of ink and substrate are two main issues of wetting in inkjet printing. One of the two issues is investigated to achieve expected printing results in general. Researches show that wettability of ink can evidently affect droplet jetting behavior, printing resolution and printing morphology, while wettability of substrate mainly affects quality of printing pattern graphing. By adjusting components of ink and substrate, surface tension of ink and surface free energy of substrate can be significantly adjusted. For substrate, it is also effective to make it under different kinds of surface treatment to change its surface physical or chemical structure, and thus change its surface free energy, or make its different regions obtain different wettabi-lities, which achieves special printing results by limitation of ink on particular region. In this review, recent progress in wetting of inkjet printing has been summarized and effect of interfacial wetting on printing results has been demonstrated from aspects of ink wettability and substrate wettability. Important questions such as printing resolution and morphology modulation have been proposed and characteristics and advantages of each methods have been discussed. As higher integration is demanded, it is sure that printing resolution needs to be further improved. As such an important role wettability plays in inkjet printing patterning, it still remains a challenge and opportunities. © 2019, Materials Review Magazine. All right reserved.