The Role of Cardiolipin in Mitochondrial Function and Neurodegenerative Diseases

被引：11

作者：

Fuentes, Jose M. ^{[1
,2
,3
]}

Morcillo, Patricia ^{[4
]}

机构：

[1] Univ Extremadura, Fac Enfermeria & Terapia Ocupac, Dept Bioquim & Biol Mol & Genet, Caceres 10003, Spain

[2] Inst Salud Carlos III CIBER CIBERNED ISCIII, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid 28029, Spain

[3] Inst Univ Invest Biosanit Extremadura INUBE, Caceres 10003, Spain

[4] Columbia Univ, Dept Neurol, New York, NY 10032 USA

来源：

CELLS | 2024年 / 13卷 / 07期

关键词：

cardiolipin; mitochondria; biological functions; neurodegenerative diseases; therapeutic applications; RESPIRATORY-CHAIN FUNCTION; IMAGING MASS-SPECTROMETRY; CYTOCHROME-C; PARKINSONS-DISEASE; OXIDATIVE-STRESS; DYSFUNCTION; MEMBRANE; COMPLEX; PROTEIN; LIPIDS;

D O I：

10.3390/cells13070609

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cardiolipin (CL) is a mitochondria-exclusive phospholipid synthesized in the inner mitochondrial membrane. CL plays a key role in mitochondrial membranes, impacting a plethora of functions this organelle performs. Consequently, it is conceivable that abnormalities in the CL content, composition, and level of oxidation may negatively impact mitochondrial function and dynamics, with important implications in a variety of diseases. This review concentrates on papers published in recent years, combined with basic and underexplored research in CL. We capture new findings on its biological functions in the mitochondria, as well as its association with neurodegenerative diseases such as Alzheimer's disease or Parkinson's disease. Lastly, we explore the potential applications of CL as a biomarker and pharmacological target to mitigate mitochondrial dysfunction.

引用

页数：18

共 132 条

[1] Cardiolipin Affects the Supramolecular Organization of ATP Synthase in Mitochondria [J].

Acehan, Devrim ;

Malhotra, Ashim ;

Xu, Yang ;

Ren, Mindong ;

Stokes, David L. ;

Schlame, Michael .

BIOPHYSICAL JOURNAL, 2011, 100 (09) :2184-2192

[2] Coincident Phosphatidic Acid Interaction Restrains Drp1 in Mitochondrial Division [J].

Adachi, Yoshihiro ;

Itoh, Kie ;

Yamada, Tatsuya ;

Cerveny, Kara L. ;

Suzuki, Takamichi L. ;

Macdonald, Patrick ;

Frohman, Michael A. ;

Ramachandran, Rajesh ;

Iijima, Miho ;

Sesaki, Hiromi .

MOLECULAR CELL, 2016, 63 (06) :1034-1043

[3] Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine [J].

Agrawal, Ira ;

Lim, Yong Shan ;

Ng, Shi-Yan ;

Ling, Shuo-Chien .

TRANSLATIONAL NEURODEGENERATION, 2022, 11 (01)

[4] The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats [J].

Allen, Mitchell E. ;

Pennington, Edward Ross ;

Perry, Justin B. ;

Dadoo, Sahil ;

Makrecka-Kuka, Marina ;

Dambrova, Maija ;

Moukdar, Fatiha ;

Patel, Hetal D. ;

Han, Xianlin ;

Kidd, Grahame K. ;

Benson, Emily K. ;

Raisch, Tristan B. ;

Poelzing, Steven ;

Brown, David A. ;

Shaikh, Saame Raza .

COMMUNICATIONS BIOLOGY, 2020, 3 (01)

[5] Imaging Mass Spectrometry of Diversified Cardiolipin Molecular Species in the Brain [J].

Amoscato, A. A. ;

Sparvero, L. J. ;

He, R. R. ;

Watkins, S. ;

Bayir, H. ;

Kagan, V. E. .

ANALYTICAL CHEMISTRY, 2014, 86 (13) :6587-6595

[6] MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes [J].

Anand, Ruchika ;

Kondadi, Arun Kumar ;

Meisterknecht, Jana ;

Golombek, Mathias ;

Nortmann, Oliver ;

Riedel, Julia ;

Peifer-Weiss, Leon ;

Brocke-Ahmadinejad, Nahal ;

Schluetermann, David ;

Stork, Bjorn ;

Eichmann, Thomas O. ;

Wittig, Ilka ;

Reichert, Andreas S. .

LIFE SCIENCE ALLIANCE, 2020, 3 (10)

[7] Detection of brain specific cardiolipins in plasma after experimental pediatric head injury [J].

Anthonymuthu, Tamil S. ;

Kenny, Elizabeth M. ;

Hier, Zachary E. ;

Clark, Robert S. B. ;

Kochanek, Patrick M. ;

Kagan, Valerian E. ;

Bayir, Huelya .

EXPERIMENTAL NEUROLOGY, 2019, 316 :63-73

[8] Diverse mitochondrial abnormalities in a new cellular model of TAFFAZZIN deficiency are remediated by cardiolipin-interacting small molecules [J].

Anzmann, Arianna F. ;

Sniezek, Olivia L. ;

Pado, Alexandra ;

Busa, Veronica ;

Vaz, Frederic M. ;

Kreimer, Simion D. ;

DeVine, Lauren R. ;

Cole, Robert N. ;

Le, Anne ;

Kirsch, Brian J. ;

Claypool, Steven M. ;

Vernon, Hilary J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 297 (03)

[9] Upregulated function of mitochondria-associated ER membranes in Alzheimer disease [J].

Area-Gomez, Estela ;

Castillo, Maria Del Carmen Lara ;

Tambini, Marc D. ;

Guardia-Laguarta, Cristina ;

de Groof, Ad J. C. ;

Madra, Moneek ;

Ikenouchi, Junichi ;

Umeda, Masato ;

Bird, Thomas D. ;

Sturley, Stephen L. ;

Schon, Eric A. .

EMBO JOURNAL, 2012, 31 (21) :4106-4123

[10] Mitochondrial lipids in neurodegeneration [J].

Aufschnaiter, Andreas ;

Kohler, Verena ;

Diessl, Jutta ;

Peselj, Carlotta ;

Carmona-Gutierrez, Didac ;

Keller, Walter ;

Buttner, Sabrina .

CELL AND TISSUE RESEARCH, 2017, 367 (01) :125-140

← 1 2 3 4 5 6 7 8 9 10 →