Autophagy in benign prostatic hyperplasia: insights and therapeutic potential

被引：1

作者：

Zhou, Xian-Zhao ^{[1
]}

Huang, Pei ^{[1
]}

Wu, Yao-Kan ^{[1
]}

Yu, Jin-Ben ^{[1
]}

Sun, Jie ^{[1
]}

机构：

[1] Zhejiang Chinese Med Univ, Affiliated Hosp 3, Dept Androl, Hangzhou 310005, Peoples R China

来源：

BMC UROLOGY | 2024年 / 24卷 / 01期

关键词：

Autophagy; Benign prostatic hyperplasia; BPH; Cell death pathways; Herbal therapy; Signaling pathways; PROTECTIVE AUTOPHAGY; MAMMALIAN AUTOPHAGY; CANCER CELLS; ROLES; FERROPTOSIS; ACTIVATION; RISK; INFLAMMATION; FINASTERIDE; SUPPRESSES;

D O I：

10.1186/s12894-024-01585-7

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Autophagy is a cellular homeostatic mechanism characterized by cyclic degradation. It plays an essential role in maintaining cellular quality and survival by eliminating dysfunctional cellular components. This process is pivotal in various pathophysiological processes. Benign prostatic hyperplasia (BPH) is a common urological disorder in middle-aged and elderly men. It frequently presents as lower urinary tract symptoms due to an increase in epithelial and stromal cells surrounding the prostatic urethra. The precise pathogenesis of BPH is complex. In recent years, research on autophagy in BPH has gained significant momentum, with accumulating evidence indicating its crucial role in the onset and progression of the disease. This review aims to outline the various roles of autophagy in BPH and elucidate potential therapeutic strategies targeting autophagy for managing BPH.

引用

页数：11

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