Frequency of Pulmonary Hypertension and Its Associated Risk Factors in End-Stage Renal Disease (ESRD) Patients on Maintenance Hemodialysis

被引:0
作者
Khemchandani, Manisha [1 ]
Nasir, Kiran [1 ]
Qureshi, Ruqaya [1 ]
Dhrolia, Murtaza [1 ]
Ahmad, Aasim [1 ]
机构
[1] Kidney Ctr Postgrad Training Inst, Nephrol, Karachi, Pakistan
关键词
pulmonary hypertension; chronic heart failure; pulmonary artery systolic pressure; maintenance hemodialysis; end stage renal disease (esrd); PREVALENCE;
D O I
10.7759/cureus.55206
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction Pulmonary hypertension (PH) is a recognized complication in patients with end -stage renal disease (ESRD undergoing maintenance hemodialysis (MHD). PH is commonly found in patients with chronic kidney disease (CKD) and ESRD. PH is associated with increased morbidity and mortality in patients with CKD. Methodology This cross-sectional study aimed to assess the prevalence of PH and its associated risk factors in MHD patients. A total of 220 ESRD patients on MHD patients at The Kidney Center, Karachi, Pakistan, aged 18-70 were included. Patients with chronic obstructive lung disease, valvular heart disease, and obstructive sleep apnea were excluded, as these conditions can be responsible for PH. PH was evaluated by echocardiography (ECHO), which was performed by a cardiologist. Results The mean age was 50.65 +/- 14.4 years, with 131 (59.5%) males and 89 (40.5%) females. The average duration on hemodialysis was 5.3 +/- 2.8 years. Hypertension (89.5%) and ischemic heart disease (24.1%) were prominent comorbidities. Hypertensive nephropathy (42.7%) was the leading cause of ESRD. Left ventricular hypertrophy was mild in most cases (85.5%), whereas regional wall motion abnormality (RWMA) was common (67.3%). The average pulmonary artery pressure was 35.2 +/- 15.3 mmHg. Out of 220 patients, 109 patients (49.8%) of them had mild PH, nine patients (4.1%) had severe PH, and 72 patients (32.7%) had moderate PH. Associations between PH and various factors were examined. RWMA, left ventricular hypertrophy, and left ventricular ejection fraction were significantly associated with PH (p < 0.001). Serum calcium and albumin levels were also associated with PH severity (p < 0.05). Other demographic and laboratory parameters did not show a significant association. Conclusion This study highlights the prevalence of PH in MHD patients and identifies associated risk factors. Understanding these associations can aid in better managing PH in ESRD patients.
引用
收藏
页数:7
相关论文
共 17 条
[1]   Pulmonary hypertension among maintenance hemodialysis patients in Somalia: a hospital-based observational study [J].
Alici, Gokhan ;
Waberi, Mohamud Mire ;
Mohamud, Mohamed Abdullahi ;
Bashir, Ahmed Muhammad ;
Genc, Omer .
EGYPTIAN HEART JOURNAL, 2022, 74 (01)
[2]  
Chhabra T, 2023, Journal of Renal and Hepatic Disorders, V7, P18, DOI [10.15586/jrenhep.v7i2.168, DOI 10.15586/JRENHEP.V7I2.168]
[3]   Pulmonary hypertension: prevalence and risk factors [J].
Faqih, Samia Ait ;
Noto-Kadou-Kaza, Befa ;
Abouamrane, Lalla Meryam ;
Mtiou, Naoufal ;
El Khayat, Selma ;
Zamd, Mohamed ;
Medkouri, Ghislaine ;
Benghanem, Mohamed Gharbi ;
Ramdani, Benyounes .
IJC HEART & VASCULATURE, 2016, 11 :87-89
[4]   Association of Mild Echocardiographic Pulmonary Hypertension With Mortality and Right Ventricular Function [J].
Huston, Jessica H. ;
Maron, Bradley A. ;
French, John ;
Huang, Shi ;
Thayer, Timothy ;
Farber-Eger, Eric H. ;
Wells, Quinn S. ;
Choudhary, Gaurav ;
Hemnes, Anna R. ;
Brittain, Evan L. .
JAMA CARDIOLOGY, 2019, 4 (11) :1112-1121
[5]   Pulmonary Hypertension Is Associated With Systemic Arterial Hypertension Among Patients With Normal Left Ventricular Diastolic Function [J].
Itelman, Edward ;
Segel, Michael J. ;
Kuperstein, Rafael ;
Feinberg, Micha ;
Segev, Amit ;
Segal, Gad ;
Maor, Elad ;
Grossman, Ehud .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2021, 10 (24)
[6]  
Li YF, 2020, CLIN INVEST MED, V43, pE44, DOI 10.25011/cim.v43i3.34631
[7]   Guidelines for Performing a Comprehensive Transthoracic Echocardiographic Examination in Adults: Recommendations from the American Society of Echocardiography [J].
Mitchell, Carol ;
Rahko, Peter S. ;
Blauwet, Lori A. ;
Canaday, Barry ;
Finstuen, Joshua A. ;
Foster, Michael C. ;
Horton, Kenneth ;
Ogunyankin, Kofo O. ;
Palma, Richard A. ;
Velazquez, Eric J. .
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2019, 32 (01) :1-64
[8]   Risk Factors of Pulmonary Hypertension in Patients on Hemodialysis: A Single Center Study [J].
Nagaraju, Shankar Prasad ;
Bhojaraja, Mohan, V ;
Paramasivam, Ganesh ;
Prabhu, Ravindra Attur ;
Rangaswamy, Dharshan ;
Rao, Indu Ramachandra ;
Shenoy, Srinivas Vinayak .
INTERNATIONAL JOURNAL OF NEPHROLOGY AND RENOVASCULAR DISEASE, 2021, 14 :487-494
[9]   Prevalence, Predictors, and Outcomes of Pulmonary Hypertension in CKD [J].
Navaneethan, Sankar D. ;
Roy, Jason ;
Tao, Kelvin ;
Brecklin, Carolyn S. ;
Chen, Jing ;
Deo, Rajat ;
Flack, John M. ;
Ojo, Akinlolu O. ;
Plappert, Theodore J. ;
Raj, Dominic S. ;
Saydain, Ghulam ;
Sondheimer, James H. ;
Sood, Ruchi ;
Steigerwalt, Susan P. ;
Townsend, Raymond R. ;
Dweik, Raed A. ;
Rahman, Mahboob .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2016, 27 (03) :877-886
[10]   Prevalence and Mortality of Pulmonary Hypertension in ESRD: A Systematic Review and Meta-analysis [J].
Schoenberg, Noah C. ;
Argula, Rahul G. ;
Klings, Elizabeth S. ;
Wilson, Kevin C. ;
Farber, Harrison W. .
LUNG, 2020, 198 (03) :535-545