First Report on Pharmacognostic, Phytochemical Investigation and In vitro Radical Scavenging Efficacy of Premna barbata from Western Himalaya

被引：1
作者：
Joshi B.C. [1 ]
Juyal V. [1 ]
Sah A.N. [1 ]
Mukhija M. [2 ]
机构：
[1] Department of Pharmaceutical Sciences, Faculty of Technology, Sir J.C. Bose Technical Campus, Bhimtal, Kumaun University, Uttarakhand, Nainital
[2] Ch. Devi Lal College of Pharmacy, Buria Road, Bhagwangarh, Jagadhri
来源：
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences | 2024年 / 94卷 / 3期
关键词：
Antioxidant; HPTLC fingerprinting; Physicochemical; Phytochemical; Premna barbata; Stembark;
D O I：
10.1007/s40011-024-01552-0
中图分类号：
学科分类号：
摘要：
Premna barbata Wall. ex Schauer is a widely used therapeutic plant belonging to family Lamiaceae and is distributed in various parts of India. Different parts of the plant were used traditionally in various ailments like arthritic pain, dropsy, herpes complex disease, etc. In the present study, systematic pharmacognostic study, preliminary phytochemical screening, HPTLC fingerprinting profile and in vitro antioxidant studies of the plant were carried out. The stembark was greyish brown in colour having rough, softly corky texture. Transverse section study and powdered microscopy revealed useful diagnostic features. The loss on drying of plant material was 5.43 ± 0.35% w/w. The total ash, water-soluble ash, and acid insoluble ash were found to be 11.66 ± 0.34, 09.00 ± 0.28 and 02.50 ± 0.12% w/w, respectively. P. barbata stem bark extractive values were found to be 08.00 ± 0.35, 06.00 ± 0.41% w/w alcohol soluble (Hot, Cold), and 13.00 ± 0.54, 11.00 ± 0.11% w/w water soluble extractives (Hot, Cold), respectively. The preliminary phytochemical screening confirms the presence of proteins, carbohydrates, steroids/triterpenoids, alkaloids, glycosides, flavonoids, and phenolic compounds in different solvent extracts. HPTLC chromatogram gives the idea about the number of phytochemicals present in the different extracts of Premna barbata. Among the different extracts, the ethyl acetate extract (EAE) showed significant antioxidant activity. These results provide major evidence that the Premna barbata have antioxidant potential. The investigation carried out will provide complete pharmacognostic profile of stem bark of Premna barbata and hence will be useful for correct recognition of the species for upcoming studies. © The Author(s), under exclusive licence to The National Academy of Sciences, India 2024.
引用
收藏
页码：685 / 695
页数：10
相关论文
共 30 条
  • [1] Aslam I., Afridi M.S.K., Pharmacognostic characterization of Beaumontia grandiflora (Roxb.) Wall leaf for taxonomic identification for quality control of a drug, J Appl Res Med Aromat Plants, 8, pp. 53-59, (2017)
  • [2] Upadhyay P., Joshi B.C., Sundriyal A., Mukhija M., Pharmacognostic standardization and physicochemical evaluation of Caesalpinia crista L. root for quality control assessment, J Nat Sci Med, 2, pp. 135-140, (2019)
  • [3] Dianita R., Jantan I., Ethnomedicinal uses, phytochemistry and pharmacological aspects of the genus Premna: a review, Pharm Biol, 55, 1, pp. 1715-1739, (2017)
  • [4] Chanotiya C.S., Yadav A.K., Singh A.K., Leaf oil composition of Premna barbata Wall. ex. Sch. from Kumaon Region of Uttarakhand, J Essent Oil Res, 21, 1, pp. 76-77, (2009)
  • [5] Naithani B.D., Flora of Chamoli. BSI publication, New Delhi, India, pp. 496-497, (1985)
  • [6] Kumar J.A., Divya J., Traditional and ethnobotanical uses premna barbata wall ex Schauer in Kumaun and Garhwal regions of Uttarakhand, India & other western Himalayan countries-a review, Int J Pharmacogn Phytochem Res, 9, 9, pp. 1213-1216, (2017)
  • [7] Joshi C.B., Juyal V., Sah N.A., Mukhija M., Ethnopharmacology, botanical description and phytochemistry of premna barbata: an unexplored medicinal plant species from lamiaceae family, Curr Tradit Med, 8, (2022)
  • [8] Nemkul C.M., Shrestha I., Ethnobotany and in vitro antimicrobial study of selected medicinal plants used by Magar community in Dhaubadi VDC, Nawalparasi district, Nepal J Nat Hist Mus, 30, pp. 141-147, (2018)
  • [9] Quattrocchi U., CRC world dictionary of medicinal and poisonous plants: Common names, scientific names, eponyms, synonyms, and etymology (Five Volume Set): CRC Press, Boca Rotan Florida: Taylor & Francis Group, (2012)
  • [10] Negi S., Shukla V., Rawat M., Pant G., Nagatsu A., Premnosidic acid, a new iridoid glycoside from Premna barbata, Indian J Chem, 43, pp. 1805-1806, (2014)
123