Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma

被引：12

作者：

Chang, Esther Wei Yin ^{[1
,2
]}

Tan, Ya Hwee ^{[1
,2
]}

Chan, Jason Yongsheng ^{[1
,2
,3
]}

机构：

[1] Natl Canc Ctr Singapore, Div Med Oncol, Singapore, Singapore

[2] Duke NUS Med Sch, Singapore, Singapore

[3] Natl Canc Ctr Singapore, Canc Discovery Hub, Singapore, Singapore

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2024年 / 17卷 / 01期

基金：

英国医学研究理事会;

关键词：

Prognosis; Precision Oncology; Epigenetics; Immunotherapy; AITL; NON-HODGKIN-LYMPHOMA; PIVOTAL PHASE-II; OPEN-LABEL; BRENTUXIMAB-VEDOTIN; CD52; EXPRESSION; SINGLE-AGENT; SALVAGE CHEMOTHERAPY; ALLOGENEIC TRANSPLANTATION; LENALIDOMIDE MONOTHERAPY; RETROSPECTIVE ANALYSIS;

D O I：

10.1186/s13045-024-01560-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Peripheral T cell lymphoma (PTCL) represents a group of heterogeneous hematological malignancies, which are notoriously challenging to treat and outcomes are typically poor. Over the past two decades, clinical prognostic indices for patient risk stratification have evolved, while several targeted agents are now available to complement combination chemotherapy in the frontline setting or as a salvage strategy. With further understanding of the molecular pathobiology of PTCL, several innovative approaches incorporating immunomodulatory agents, epigenetic therapies, oncogenic kinase inhibitors and immunotherapeutics have come to the forefront. In this review, we provide a comprehensive overview of the progress in developing clinical prognostic indices for PTCL and describe the broad therapeutic landscape, emphasizing novel targetable pathways that have entered early phase clinical studies.

引用

页数：20

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