Polyhydroxy structure orchestrates the intrinsic antibacterial property of acrylamide hydrogel as a versatile wound-healing dressing

被引:0
|
作者
Zhang, Lu [1 ]
Tang, Yu-Jiao [1 ]
Zhang, Wen-Qing [1 ]
Wang, Jian [1 ]
Cai, Yu-Jian [1 ]
Qin, Tian-Yi [1 ]
Zhang, Deteng [2 ]
Wang, Zhao-Hui [1 ]
Wang, Ya-Long [1 ]
机构
[1] Hainan Univ, Sch Biomed Engn, State Key Lab Digital Med Engn, Key Lab Biomed Engn Hainan Prov, Sanya, Hainan, Peoples R China
[2] Qingdao Univ, Inst Neuroregenerat & Neurorehabil, Qingdao, Peoples R China
基金
海南省自然科学基金; 中国国家自然科学基金;
关键词
antibacterial hydrogels; wound healing; inherent antimicrobial; polyhydroxy; acrylamide;
D O I
10.3389/fbioe.2024.1396892
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Hydrogel is considered as a promising candidate for wound dressing due to its tissue-like flexibility, good mechanical properties and biocompatibility. However, traditional hydrogel dressings often fail to fulfill satisfied mechanical, antibacterial, and biocompatibility properties simultaneously, due to the insufficient intrinsic bactericidal efficacy and the addition of external antimicrobial agents. In this paper, hydroxyl-contained acrylamide monomers, N-Methylolacrylamide (NMA) and N-[Tris (hydroxymethyl)methyl] acrylamide (THMA), are employed to prepare a series of polyacrylamide hydrogel dressings xNMA-yTHMA, where x and y represent the mass fractions of NMA and THMA in the hydrogels. We have elucidated that the abundance of hydroxyl groups determines the antibacterial effect of the hydrogels. Particularly, hydrogel 35NMA-5THMA exhibits excellent mechanical properties, with high tensile strength of 259 kPa and large tensile strain of 1737%. Furthermore, the hydrogel dressing 35NMA-5THMA demonstrates remarkable inherent antibacterial without exogenous antimicrobial agents owing to the existence of abundant hydroxyl groups. Besides, hydrogel dressing 35NMA-5THMA possesses excellent biocompatibility, in view of marginal cytotoxicity, low hemolysis ratio, and negligible inflammatory response and organ toxicity to mice during treatment. Encouragingly, hydrogel 35NMA-5THMA drastically promote the healing of bacteria-infected wound in mice. This study has revealed the importance of polyhydroxyl in the antibacterial efficiency of hydrogels and provided a simplified strategy to design wound healing dressings with translational potential.
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页数:10
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