Clinical and molecular correlates of tumor aneuploidy in metastatic non-small cell lung cancer

被引：3

作者：

Spurr, Liam F. ^{[1
,2
]}

Pitroda, Sean P. ^{[2
,3
]}

机构：

[1] Univ Chicago, Pritzker Sch Med, Chicago, IL USA

[2] Univ Chicago, Dept Radiat & Cellular Oncol, Chicago, IL 60637 USA

[3] Univ Chicago, Ludwig Ctr Metastasis Res, 5758 South Maryland Ave,MC 9006, Chicago, IL 60637 USA

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

关键词：

Aneuploidy; Immunotherapy; Anti-tumor immunity; Lung cancer; GENE;

D O I：

10.1038/s41598-024-66062-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent studies have linked elevated tumor aneuploidy to anti-tumor immune suppression and adverse survival following immunotherapy. Herein, we provide supportive evidence for tumor aneuploidy as a biomarker of response to immunotherapy in patients with non-small cell lung cancer (NSCLC). We identify a dose-response relationship between aneuploidy score and patient outcomes. In two independent NSCLC cohorts (n = 659 patients), we demonstrate a novel association between elevated aneuploidy and non-smoking-associated oncogenic driver mutations. Lastly, we report enrichment of TERT amplification and immune-suppressive phenotypes of highly aneuploid NSCLC. Taken together, our findings emphasize a potentially critical role for tumor aneuploidy in guiding immunotherapy treatment strategies.

引用

页数：10

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