A carrier-free tri-component nanoreactor for multi-pronged synergistic cancer therapy

被引:3
作者
Shi, Huifang [1 ,2 ]
Zheng, Fangying [1 ,2 ]
Zheng, Yilin [1 ,2 ]
Sun, Xianbin [1 ,2 ]
Chen, Haijun [3 ]
Gao, Yu [1 ,2 ,4 ]
机构
[1] Fuzhou Univ, Coll Chem, Canc Metastasis Alert & Prevent Ctr, Fuzhou 350116, Fujian, Peoples R China
[2] Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Canc Metastasis Chemoprevent &, Fuzhou 350116, Fujian, Peoples R China
[3] Fuzhou Univ, Fujian Prov Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Peoples R China
[4] Fuzhou Univ, 2 Xueyuan Rd,Yangguang Bldg,6FL, Fuzhou 350108, Fujian, Peoples R China
基金
中国国家自然科学基金;
关键词
Tri-component; Carrier; -free; Synergistic therapy; Tumor microenvironment; Ferroptosis; TUMOR; PEROXYNITRITE; FERROPTOSIS; HYPOXIA; RELEASE;
D O I
10.1016/j.jphotobiol.2024.112886
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Non-invasive therapies such as photodynamic therapy (PDT) and chemodynamic therapy (CDT) have received wide attention due to their low toxicity and side effects, but their efficacy is limited by the tumor microenvironment (TME), and monotherapy cannot achieve satisfactory efficacy. In this work, a multifunctional nanoparticle co -assembled from oleanolic acid (OA), chlorin e6 (Ce6) and hemin was developed. The as -constructed nanoparticle named OCH with diameters of around 130 nm possessed good biostability, pH/GSH dual -responsive drug release properties, and remarkable cellular internalization and tumor accumulation capabilities. OCH exhibited prominent catalytic activities to generate center dot OH, deplete GSH, and produce O 2 to overcome the hypoxia TME, thus potentiating the photodynamic and chemodynamic effect. In addition, OCH can induce the occurrence of ferroptosis in both ferroptosis-sensitive and ferroptosis-resistant cancer cells. The multi -pronged effects of OCH including hypoxia alleviation, GSH depletion, ferroptosis induction, CDT and PDT effects jointly facilitate excellent anticancer effects in vitro and in vivo . Hence, this work will advance the development of safe and effective clinically transformable nanomedicine by employing clinically -applied agents to form drug combinations for efficient multi -pronged combination cancer therapy.
引用
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页数:13
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