Association between frailty and hypoproteinaemia in older patients: meta-analysis and systematic review

被引:2
作者
Zhang, Linxue [1 ,2 ]
Yang, Pingping [1 ,2 ]
Yin, Furong [1 ,2 ]
Zhang, Jinbo [1 ,2 ]
Zhao, Benli [1 ,2 ]
Zhou, Jiamei [1 ,2 ]
机构
[1] Zunyi Med Univ, Affiliated Hosp, Nursing Dept, Zunyi 563000, Peoples R China
[2] Zunyi Med Univ, Nursing Coll, Zunyi 563000, Peoples R China
关键词
Frailty; Hypoproteinaemia; Systematic review; Meta-analysis; Ageing; CLINICAL-OUTCOMES; MORTALITY; QUALITY; SCALE; RISK; LIFE;
D O I
10.1186/s12877-024-05275-9
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
ObjectiveFrailty and hypoproteinaemia are common in older individuals. Although there is evidence of a correlation between frailty and hypoproteinaemia, the relationship between frailty and hypoproteinaemia in hospitalized/critically ill and older community residents has not been clarified. Therefore, the aim of our meta-analysis was to evaluate the associations between frailty and hypoproteinaemia in different types of patients.MethodsA systematic retrieval of articles published in the PubMed, Embase, Medline, Web of Science, Cochrane, Wanfang, and CNKI databases from their establishment to April 2024 was performed to search for studies on the associations between severity of frailty or prefrailty and hypoproteinaemia in older adults. The Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality Scale were used to assess study quality.ResultsTwenty-two studies were included including 90,351 frail older people were included. Meta-analysis revealed an association between frailty or prefrailty and hypoproteinaemia (OR = 2.37, 95% CI: 1.47, 3.83; OR = 1.62, 95% CI: 1.23, 2.15), there was no significant difference in the risk of hypoproteinaemia between patients with severe frailty and those with low or moderate frailty (OR = 0.62, 95% CI:0.44, 0.87). The effect of frailty on the occurrence of hypoproteinaemia was more obvious in hospitalized patients/critically ill patients than in surgical patients (OR = 3.75, 95% CI: 2.36, 5.96), followed by older community residents (OR = 2.30, 95% CI: 1.18, 4.49).ConclusionFrailty is associated with hypoproteinaemia in surgical patients, hospitalized older patients and older community residents. Future studies should focus on the benefits of albumin supplementation in preventing or alleviating frailty and related outcomes in the future.
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页数:10
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