Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review

被引:1
作者
Ronchi, Andrea [1 ]
Vitiello, Paola [2 ]
D'Abbronzo, Giuseppe [1 ]
Caccavale, Stefano [2 ]
Argenziano, Giuseppe [2 ]
Sica, Antonello [3 ]
Alfano, Roberto [4 ]
Savarese, Giovanni [5 ]
Berretta, Massimiliano [6 ]
Cozzolino, Immacolata [1 ]
Franco, Renato [1 ]
机构
[1] Univ Campania Luigi Vanvitelli, Dept Mental Hlth & Phys & Prevent Med, Pathol Unit, I-80138 Naples, Italy
[2] Univ Campania Luigi Vanvitelli, Dept Mental & Phys Hlth & Prevent Med, Dermatol Unit, I-80131 Naples, Italy
[3] Univ Campania Luigi Vanvitelli, Dept Precis Med, Oncol Unit, I-80131 Naples, Italy
[4] Univ Campania Luigi Vanvitelli, Dept Anesthesiol, Surg & Emergency, I-80138 Naples, Italy
[5] Ctr Polidiagnost Strumentale srl, AMES, I-80013 Naples, Italy
[6] Univ Messina, Dept Clin & Expt Med, I-98122 Messina, Italy
关键词
primary cutaneous lymphoma; follicle center lymphoma; diffuse large B-cell lymphoma; leg type; FOLLICULAR LYMPHOMAS; LEG TYPE; CLASSIFICATION; LANDSCAPE; FEATURES; T(14/18); SERIES; BCL2;
D O I
10.3390/ijms24076204
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Most primary cutaneous lymphomas consist of T-cell lymphomas or small cell lymphomas; however, the skin may also be affected by lymphomas with large cell morphology, as a primary or secondary localization. A minority of cases consist of primary cutaneous B-cell lymphomas (PCBCLs). PCBCLs are a heterogeneous group of rare neoplasms with an overlapping morphological and immunohistochemical picture of the different subtypes. Nevertheless, differential diagnosis in the setting of this group of neoplasms is mandatory to identify the correct therapy and prognosis, but it may be challenging since, due to the rarity of these neoplasms, they may not always be familiar to pathologists. Indeed, immunohistochemistry may not be enough to distinguish the different histotypes, which overlap in immunohistochemical features. Furthermore, the ever-increasing knowledge of the molecular features of systemic B-cell lymphomas, such as gene rearrangements with clinical significance, has led in recent years to further investigation into the molecular landscape of PCBCLs with large cell morphology. This work aimed to provide a practical diagnostic guide for pathologists dealing with primary cutaneous large B-cell lymphomas.
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页数:12
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