Animal models for the treatment of human diseases

被引：0

作者：

Jura, Jacek ^{[1
]}

机构：

[1] Natl Res Inst Anim Prod, Dept Reprod Biotechnol & Cryoconservat, PL-32083 Krakow, Poland

来源：

ANNALS OF ANIMAL SCIENCE | 2024年 / 24卷 / 04期

关键词：

animal models; natural models; induced models; transgenic models; xenotransplantation; human trials;

D O I：

10.2478/aoas-2024-0058

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Currently, studies conducted on animal models provide new insight into the aetiology and course of various pathological conditions in humans. Due to the cause of disease, animal models can be divided into two categories: natural models, such as nude mice, and induced models, such as transgenic pigs. This article discusses several examples of animal models and their contributions to the development of effective therapies for human diseases such as muscular dystrophy, cystic fibrosis, and atherosclerosis. In addition, we presented the latest news on gene therapy, xenotransplantation, and drug trials in humans and animals.

引用

页码：1153 / 1159

页数：7

共 30 条

[1] Reduced Tumorigenesis in p53 Knockout Mice Exposed In Utero to Low-Dose Vitamin E [J].

Chen, Connie S. ;

Squire, Jeremy A. ;

Wells, Peter G. .

CANCER, 2009, 115 (07) :1563-1575

[2] Targeting G542X CFTR nonsense alleles with ELX-02 restores CFTR function in human-derived intestinal organoids [J].

Crawford, Daniel K. ;

Mullenders, Jasper ;

Pott, Johanna ;

Boj, Sylvia F. ;

Landskroner-Eiger, Shira ;

Goddeeris, Matthew M. .

JOURNAL OF CYSTIC FIBROSIS, 2021, 20 (03) :436-442

[3] Obesity Development in a Miniature Yucatan Pig Model: A Multi-compartmental Metabolonnics Study on Cloned and Normal Pigs Fed Restricted or Ad Libitum High-Energy Diets [J].

Curtasu, Mihai V. ;

Knudsen, Knud Erik B. ;

Callesen, Henrik ;

Purup, Stig ;

Stagsted, Jan ;

Hedemann, Mette S. .

JOURNAL OF PROTEOME RESEARCH, 2019, 18 (01) :30-47

[4]

Dai Y., 2002, NATBIOTECHNOL

[5] The porcine translational research database: a manually curated, genomics and proteomics-based research resource [J].

Dawson, Harry D. ;

Chen, Celine ;

Gaynor, Brady ;

Shao, Jonathan ;

Urban, Joseph F., Jr. .

BMC GENOMICS, 2017, 18

[6] CYSTIC-FIBROSIS IN THE MOUSE BY TARGETED INSERTIONAL MUTAGENESIS [J].

DORIN, JR ;

DICKINSON, P ;

ALTON, EWFW ;

SMITH, SN ;

GEDDES, DM ;

STEVENSON, BJ ;

KIMBER, WL ;

FLEMING, S ;

CLARKE, AR ;

HOOPER, ML ;

ANDERSON, L ;

BEDDINGTON, RSP ;

PORTEOUS, DJ .

NATURE, 1992, 359 (6392) :211-215

[7] Muscular dystrophy: Experimental animal models and therapeutic approaches (Review) [J].

Gaina, Gisela ;

Popa , Alexandra .

EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021, 21 (06)

[8]

Jura J., 2006, BIOTECHNOLOGIA, V1, P151

[9] Molecular targets to treat muscular dystrophies [J].

Kinter, Jochen ;

Sinnreich, Michael .

SWISS MEDICAL WEEKLY, 2014, 144

[10] Success for cross-species heart transplants [J].

Knosalla, Christoph .

NATURE, 2018, 564 (7736) :352-353

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