Altered Functional Connectivity of the Multisensory Vestibular Cortex in Patients with Chronic Unilateral Vestibulopathy

Background: Chronic unilateral vestibulopathy (CUVP) is a common chronic vestibular syndrome; the mechanisms of central vestibular compensation in CUVP are rarely studied.Methods: This study analyzed the data of 18 patients with CUVP and 18 healthy controls (HCs) and used seed-based functional connectivity (FC) and voxel-mirrored homotopic connectivity (VMHC) analyses to explore the FC alterations.Results: Compared with HCs, patients with CUVP showed decreased FC between the left dorsolateral superior frontal gyrus and the right hippocampus; the left middle frontal gyrus and the right posterior cingulate gyrus, the right hippocampus, the right parahippocampal gyrus. There is also a reduction in FC between the left and right insula. There was enhanced FC between the left supplementary motor area (SMA) and the bilateral superior occipital gyrus, the left hippocampus and the left posterior cingulate gyrus, as well as a the left middle temporal gyrus (p = 0.03). Additionally,VMHC was decreased between the bilateral medial superior frontal gyrus, the bilateral precentral gyrus, and the bilateral postcentral gyrus (p = 0.001). The zVMHC values in the bilateral superior frontal gyrus and the precentral gyrus were both negatively corrected with the Dizziness Handicap Inventory (DHI) score.well asConclusions: Altered FC in regions of bilateral multisensory vestibular cortex existed in patients with CUVP. Decreased FC and VMHC in the bilateral multisensory vestibular cortex may affect vestibular information integration, thus affecting self-motion perception, spatial orientation, and postural control. Impact Statement We applied seed-based functional connectivity (FC) and voxel-mirrored homotopic connectivity (VMHC) analyses to investigate the changes in FC patterns across the whole brain and between the two hemispheres in patients with CUVP and found that patients with CUVP showed reduced FC in the multisensory vestibular cortex areas on the affected side and enhanced FC on the healthy side, suggesting that central vestibular compensation mainly occurs in brain regions on the healthy side of the patients. Reduced FC and VMHC in related regions of bilateral vestibular cortex may affect the integration of bilateral vestibular information, resulting in the occurrence of chronic dizziness/instability.