Endocrine Regulation of Aging in the Fruit Fly Drosophila melanogaster

被引：3

作者：

Qian, Qingyin ^{[1
]}

Niwa, Ryusuke ^{[2
]}

机构：

[1] Univ Tsukuba, Grad Sch Comprehens Human Sci, Tennodai 1-1-1, Tsukuba, Ibaraki 3058577, Japan

[2] Univ Tsukuba, Life Sci Ctr Survival Dynam, Tsukuba Adv Res Alliance TARA, Tennodai 1-1-1, Tsukuba, Ibaraki 3058577, Japan

来源：

ZOOLOGICAL SCIENCE | 2024年 / 41卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

Drosophila melanogaster; aging; interorgan communication; insulin-like peptide; ecdysone; ecdysteroid; juvenile hormone; dopamine; serotonin; enteroendocrine hormone; LIFE-SPAN EXTENSION; JUVENILE-HORMONE; DIETARY RESTRICTION; SIGNALING PATHWAY; PEPTIDE-HORMONES; GENETIC ABLATION; STRESS-RESPONSE; CELLS; DOPAMINE; ECDYSONE;

D O I：

10.2108/zs230056

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

The past few decades have witnessed increasing research clarifying the role of endocrine signaling in the regulation of aging in both vertebrates and invertebrates. Studies using the model organism fruit fly Drosophila melanogaster have largely advanced our understanding of evolutionarily conserved mechanisms in the endocrinology of aging and anti-aging. Mutations in single genes involved in endocrine signaling modify lifespan, as do alterations of endocrine signaling in a tissue- or cell-specific manner, highlighting a central role of endocrine signaling in coordinating the crosstalk between tissues and cells to determine the pace of aging. Here, we review the current landscape of research in D. melanogaster that offers valuable insights into the endocrine-governed mechanisms which influence lifespan and age-related physiology.

引用

页码：4 / 13

页数：10

共 120 条

[11] An overview of the insulin signaling pathway in model organisms Drosophila melanogaster and Caenorhabditis elegans [J].

Biglou, Sanaz G. ;

Bendena, William G. ;

Chin-Sang, Ian .

PEPTIDES, 2021, 145

[12] Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila [J].

Biteau, Benoit ;

Karpac, Jason ;

Supoyo, Stephen ;

DeGennaro, Matthew ;

Lehmann, Ruth ;

Jasper, Heinrich .

PLOS GENETICS, 2010, 6 (10) :1-15

[13] Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila [J].

Bjedov, Ivana ;

Cocheme, Helena M. ;

Foley, Andrea ;

Wieser, Daniela ;

Woodling, Nathaniel S. ;

Castillo-Quan, Jorge Ivan ;

Norvaisas, Povilas ;

Lujan, Celia ;

Regan, Jenny ;

Toivonen, Janne M. ;

Murphy, Michael P. ;

Thornton, Janet ;

Kinghorn, Kerri J. ;

Neufeld, Thomas P. ;

Cabreiro, Filipe ;

Partridge, Linda .

PLOS GENETICS, 2020, 16 (11)

[14] Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster [J].

Bjedov, Ivana ;

Toivonen, Janne M. ;

Kerr, Fiona ;

Slack, Cathy ;

Jacobson, Jake ;

Foley, Andrea ;

Partridge, Linda .

CELL METABOLISM, 2010, 11 (01) :35-46

[15] Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system [J].

Bolukbasi, Ekin ;

Woodling, Nathaniel S. ;

Ivanov, Dobril K. ;

Adcott, Jennifer ;

Foley, Andrea ;

Rajasingam, Arjunan ;

Gittings, Lauren M. ;

Aleyakpo, Benjamin ;

Niccoli, Teresa ;

Thornton, Janet M. ;

Partridge, Linda .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (08)

[16] Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity [J].

Bolukbasi, Ekin ;

Khericha, Mobina ;

Regan, Jennifer C. ;

Ivanov, Dobril K. ;

Adcott, Jennifer ;

Dyson, Miranda C. ;

Nespital, Tobias ;

Thornton, Janet M. ;

Alic, Nazif ;

Partridge, Linda .

CELL REPORTS, 2017, 21 (03) :641-653

[17] THE TITER OF JUVENILE-HORMONE DURING THE PUPAL AND ADULT STAGES OF THE LIFE-CYCLE OF DROSOPHILA-MELANOGASTER [J].

BOWNES, M ;

REMBOLD, H .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1987, 164 (03) :709-712

[18] Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands [J].

Broughton, SJ ;

Piper, MDW ;

Ikeya, T ;

Bass, TM ;

Jacobson, J ;

Driege, Y ;

Martinez, P ;

Hafen, E ;

Withers, DJ ;

Leevers, SJ ;

Partridge, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (08) :3105-3110

[19] Reduction of DILP2 in Drosophila Triages a Metabolic Phenotype from Lifespan Revealing Redundancy and Compensation among DILPs [J].

Broughton, Susan ;

Alic, Nazif ;

Slack, Cathy ;

Bass, Timothy ;

Ikeya, Tomoatsu ;

Vinti, Giovanna ;

Tommasi, Anna Maria ;

Driege, Yasmine ;

Hafen, Ernst ;

Partridge, Linda .

PLOS ONE, 2008, 3 (11)

[20] DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition [J].

Broughton, Susan J. ;

Slack, Cathy ;

Alic, Nazif ;

Metaxakis, Athanasios ;

Bass, Timothy M. ;

Driege, Yasmine ;

Partridge, Linda .

AGING CELL, 2010, 9 (03) :336-346

← 1 2 3 4 5 6 7 8 9 10 →