Endocrine Regulation of Aging in the Fruit Fly Drosophila melanogaster

被引：3
作者：
Qian, Qingyin [1 ]
Niwa, Ryusuke [2 ]
机构：
[1] Univ Tsukuba, Grad Sch Comprehens Human Sci, Tennodai 1-1-1, Tsukuba, Ibaraki 3058577, Japan
[2] Univ Tsukuba, Life Sci Ctr Survival Dynam, Tsukuba Adv Res Alliance TARA, Tennodai 1-1-1, Tsukuba, Ibaraki 3058577, Japan
来源：
ZOOLOGICAL SCIENCE | 2024年 / 41卷 / 01期
基金：
日本科学技术振兴机构;
关键词：
Drosophila melanogaster; aging; interorgan communication; insulin-like peptide; ecdysone; ecdysteroid; juvenile hormone; dopamine; serotonin; enteroendocrine hormone; LIFE-SPAN EXTENSION; JUVENILE-HORMONE; DIETARY RESTRICTION; SIGNALING PATHWAY; PEPTIDE-HORMONES; GENETIC ABLATION; STRESS-RESPONSE; CELLS; DOPAMINE; ECDYSONE;
D O I：
10.2108/zs230056
中图分类号：
Q95 [动物学];
学科分类号：
071002 ;
摘要：
The past few decades have witnessed increasing research clarifying the role of endocrine signaling in the regulation of aging in both vertebrates and invertebrates. Studies using the model organism fruit fly Drosophila melanogaster have largely advanced our understanding of evolutionarily conserved mechanisms in the endocrinology of aging and anti-aging. Mutations in single genes involved in endocrine signaling modify lifespan, as do alterations of endocrine signaling in a tissue- or cell-specific manner, highlighting a central role of endocrine signaling in coordinating the crosstalk between tissues and cells to determine the pace of aging. Here, we review the current landscape of research in D. melanogaster that offers valuable insights into the endocrine-governed mechanisms which influence lifespan and age-related physiology.
引用
收藏
页码：4 / 13
页数：10
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