Comparison between Two Different Synthesis Methods of Strontium-Doped Hydroxyapatite Designed for Osteoporotic Bone Restoration

被引：2

作者：

Codrea, Cosmin Iulian ^{[1
,2
]}

Lincu, Daniel ^{[1
,2
]}

Atkinson, Irina ^{[2
]}

Culita, Daniela C. ^{[2
]}

Croitoru, Alexa-Maria ^{[1
,3
,4
]}

Dolete, Georgiana ^{[1
,3
,4
]}

Trusca, Roxana ^{[1
,3
,4
]}

Vasile, Bogdan Stefan ^{[1
,3
,4
]}

Stan, Miruna Silvia ^{[5
]}

Ficai, Denisa ^{[1
,3
,4
]}

Ficai, Anton ^{[1
,3
,4
,6
]}

机构：

[1] Natl Univ Sci & Technol Politehn Bucharest, Fac Chem Engn & Biotechnol, Bucharest 060042, Romania

[2] Romanian Acad, Dept Oxide Cpds & Mat Sci, Inst Phys Chem Ilie Murgulescu, Bucharest 060021, Romania

[3] Natl Univ Sci & Technol Politehn Bucharest, Fac Chem Engn & Biotechnol, Natl Res Ctr Micro & Nanomat, Splaiul Independentei 313, Bucharest 060042, Romania

[4] Natl Univ Sci & Technol Politehn Bucharest, Natl Ctr Food Safety, Splaiul Independentei 313, Bucharest 060042, Romania

[5] Univ Bucharest, Fac Biol, Dept Biochem & Mol Biol, Splaiul Independentei 91-95, Bucharest 050095, Romania

[6] Acad Romanian Scientists, Ilfov St 3, Bucharest 050044, Romania

来源：

MATERIALS | 2024年 / 17卷 / 07期

关键词：

hydroxyapatite nano-powder; co-precipitation; hydrothermal; strontium; NANO-HYDROXYAPATITE; SR;

D O I：

10.3390/ma17071472

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Development of efficient controlled local release of drugs that prevent systemic side effects is a challenge for anti-osteoporotic treatments. Research for new bone-regeneration materials is of high importance. Strontium (Sr) is known as an anti-resorptive and anabolic agent useful in treating osteoporosis. In this study, we compared two different types of synthesis used for obtaining nano hydroxyapatite (HA) and Sr-containing nano hydroxyapatite (SrHA) for bone tissue engineering. Synthesis of HA and SrHA was performed using co-precipitation and hydrothermal methods. Regardless of the synthesis route for the SrHA, the intended content of Sr was 1, 5, 10, 20, and 30 molar %. The chemical, morphological, and biocompatibility properties of HA and SrHA were investigated. Based on our results, it was shown that HA and SrHA exhibited low cytotoxicity and demonstrated toxic behavior only at higher Sr concentrations.

引用

页数：23

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