Synthesis and Antibacterial Activities of Sulfonamides Derivatives Bearing 1, 2, 3-Triazole Moiety

2-Chloro-N-(4-sulfamoylphenyl)acetamide(Ⅱ) was prepared from p-amino benzene sulfonamide with chloroacetyl chloride. Then, ten 1,2,3-triazolyl sulfonamides (Ⅲa~j) were prepared using a known one-pot procedure starting from intermediate Ⅱ, sodium azide and terminal alkynes. The target compounds were characterized by FTIR, 1HNMR, 13CNMR,ESI-MS and elemental analysis and their antibacterial activities were determined by using double broth dilution method. The results showed that all the tested compounds exhibited antibacterial activities against S.aureus and E.coli to a certain extent. In particular, the compound 2-[4-(3-fluorophenyl)-1H-1, 2, 3-triazol-1-yl]-N-(4-sulfamoylphenyl)acetamide (Ⅲh) with a minimal inhibitory concentration (MIC) value of 0.25 mg/L against E.coli was similar to the positive control drug (ciprofloxacin). © 2019, Editorial Office of FINE CHEMICALS. All right reserved.