Hyaluronic acid functionalized iron-platinum nanoparticles for photothermal therapy and photoacoustic imaging

被引：5

作者：

Phan, Thi Tuong Vy ^{[1
,2
,5
]}

Mondal, Sudip ^{[3
]}

Santhamoorthy, Madhappan ^{[4
]}

Truong, Thi Thuy ^{[4
]}

Nguyen, Thanh Phuoc ^{[6
]}

Oh, Junghwan ^{[5
,7
,8
]}

机构：

[1] Duy Tan Univ, Inst Res & Dev, Ctr Adv Chem, Danang 550000, Vietnam

[2] Duy Tan Univ, Dept Environm & Chem Engn, Danang 550000, Vietnam

[3] Pukyong Natl Univ, Digital Healthcare Res Ctr, Busan 48513, South Korea

[4] Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, South Korea

[5] Pukyong Natl Univ, Ind 4-0 Convergence Bion Engn, Busan 48513, South Korea

[6] Cao Thang Tech Coll, Dept Mechatron, Ho Chi Minh City 700000, Vietnam

[7] Ohlabs Corp, Busan 48513, South Korea

[8] Pukyong Natl Univ, Dept Biomed Engn, Busan 48513, South Korea

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2024年 / 238卷

基金：

新加坡国家研究基金会;

关键词：

FePt nanoparticles; Hyaluronic acid; Photo-absorber; Photothermal therapy; Photoacoustic imaging; IN-VIVO; TOXICITY;

D O I：

10.1016/j.colsurfb.2024.113910

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

This study represents an innovative approach to construct multi-functional nanoplatforms for cancer diagnosis and therapy by combining hyaluronic acid (HA) with iron-platinum nanoparticles (FePt NPs). These HA-coated FePt NPs, referred to as FePt@HA NPs, demonstrated remarkable biocompatibility, high absorption, and excellent light-to-heat conversion properties in the near-infrared (NIR) region, making them ideal candidates for photothermal therapy (PTT). In vitro studies revealed their effective cancer cell eradication under NIR laser irradiation, while in vivo experiments on mice showcased their superior heating capabilities. Moreover, FePt@HA NPs exhibited a distinct and strong photoacoustic (PA) signal, facilitating enhanced and precise intra-tumoral PA imaging. Our results highlight the potential of FePt@HA NPs as promising photothermal agents for future PTT applications. They offer high selectivity, precision, and minimal side effects in cancer treatment, along with their valuable PA imaging application for tumor localization and characterization.

引用

页数：9

共 28 条

[1] Magnetically guided theranostics: montmorillonite-based iron/platinum nanoparticles for enhancing in situ MRI contrast and hepatocellular carcinoma treatment [J].