First-trimester exposure to tofacitinib in ulcerative colitis: A case report of a healthy newborn and literature review

被引：2

作者：

Arzivian, Arteen ^{[1
,2
,3
]}

Zhang, Eva ^{[1
]}

Laube, Robyn ^{[1
]}

Leong, Rupert ^{[1
]}

机构：

[1] Macquarie Univ Hosp, Dept Gastroenterol & Hepatol, Sydney, NSW, Australia

[2] Macquarie Univ, Macquarie Med Sch, Fac Med Hlth & Human Sci, Sydney, NSW, Australia

[3] Suite 404,Level 4,2 Technol Pl, Sydney, NSW 2109, Australia

来源：

CLINICAL CASE REPORTS | 2024年 / 12卷 / 04期

关键词：

case report; inflammatory bowel diseases; Janus kinase inhibitors; pregnancy; tofacitinib; ulcerative colitis; PREGNANCY; ARTHRITIS; SAFETY; DRUGS;

D O I：

10.1002/ccr3.8764

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tofacitinib is contraindicated in pregnancy. We present a patient with ulcerative colitis on tofacitinib who had an unplanned pregnancy. Tofacitinib was ceased, switched to vedolizumab, and she gave birth to a healthy newborn at term. Case reports of reassuring outcomes provide real-world data that assists decision-making for future patients. The timeline of events during pregnancy in our patient with ulcerative colitis who was in remission on tofacitinib 10 mg twice daily and found to be pregnant at 6 weeks of gestation.image

引用

页数：4

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