The cell cycle revisited: DNA replication past S phase preserves genome integrity

被引:4
|
作者
Bournaka, Spyridoula [1 ]
Badra-Fajardo, Nibal [1 ]
Arbi, Marina [1 ]
Taraviras, Stavros [2 ]
Lygerou, Zoi [1 ]
机构
[1] Univ Patras, Med Sch, Dept Gen Biol, Patras 26504, Greece
[2] Univ Patras, Med Sch, Dept Physiol, Patras 26504, Greece
关键词
MiDAS (mitotic DNA synthesis); Checkpoint; G2; replication; Break -induced replication (BIR); Under; -replication; COMMON FRAGILE SITE; CHROMOSOME SEGREGATION; MOLECULAR-MECHANISMS; DELAYED REPLICATION; HUMAN TELOMERES; RE-REPLICATION; RIBOSOMAL DNA; DAMAGE; INSTABILITY; INITIATION;
D O I
10.1016/j.semcancer.2024.02.002
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Accurate and complete DNA duplication is critical for maintaining genome integrity. Multiple mechanisms regulate when and where DNA replication takes place, to ensure that the entire genome is duplicated once and only once per cell cycle. Although the bulk of the genome is copied during the S phase of the cell cycle, increasing evidence suggests that parts of the genome are replicated in G2 or mitosis, in a last attempt to secure that daughter cells inherit an accurate copy of parental DNA. Remaining unreplicated gaps may be passed down to progeny and replicated in the next G1 or S phase. These findings challenge the long-established view that genome duplication occurs strictly during the S phase, bridging DNA replication to DNA repair and providing novel therapeutic strategies for cancer treatment.
引用
收藏
页码:45 / 55
页数:11
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