Consistency of covid-19 trial preprints with published reports and impact for decision making: retrospective review

被引:13
|
作者
Zeraatkar, Dena [1 ]
Pitre, Tyler [2 ]
Leung, Gareth [3 ]
Cusano, Ellen [4 ]
Agarwal, Arnav [5 ]
Khalid, Faran [2 ]
Escamilla, Zaira [2 ]
Cooper, Matthew Adam [6 ]
Ghadimi, Maryam [2 ]
Wang, Ying [7 ]
Verdugo-Paiva, Francisca [8 ,9 ]
Rada, Gabriel [8 ]
Kum, Elena
Qasim, Anila [1 ]
Bartoszko, Jessica Julia [2 ]
Siemieniuk, Reed Alexander Cunningham [1 ]
Patel, Chirag [10 ]
Guyatt, Gordon [2 ]
Brignardello-Petersen, Romina [11 ]
机构
[1] McMaster Univ, Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada
[2] McMaster Univ, Hamilton, ON, Canada
[3] Univ Ottawa, Ottawa, ON, Canada
[4] Univ Calgary, Internal Med Residency Program, Cumming Sch Med, Calgary, AB, Canada
[5] Univ Toronto, Dept Med, Toronto, ON, Canada
[6] Univ Alberta, Dept Med, Fac Med & Dent, Edmonton, AB, Canada
[7] Capital Med Univ, Beijing Chao Yang Hosp, Dept Pharm, Beijing, Peoples R China
[8] Epistemonikos Fdn, Santiago, Chile
[9] Pontificia Univ Catolica Chile, Cochrane Chile Associated Ctr, UC Evidence Ctr, Santiago, Chile
[10] Harvard Med Sch, Biomed Informat, Boston, MA USA
[11] Univ Chile, Fac Dent, Santiago, Chile
来源
BMJ MEDICINE | 2022年 / 1卷 / 01期
基金
加拿大健康研究院;
关键词
COVID-19; Public health; PUBLICATION; GRADE; TIME;
D O I
10.1136/bmjmed-2022-000309
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE To assess the trustworthiness (ie, complete and consistent reporting of key methods and results between preprint and published trial reports) and impact (ie, effects of preprints on meta-analytic estimates and the certainty of evidence) of preprint trial reports during the covid-19 pandemic. DESIGN Retrospective review. DATA SOURCES World Health Organization covid-19 database and the Living Overview of the Evidence (L-OVE) covid-19 platform by the Epistemonikos Foundation (up to 3 August 2021). MAIN OUTCOME MEASURES Comparison of characteristics of covid-19 trials with and without preprints, estimates of time to publication of covid-19 preprints, and description of differences in reporting of key methods and results between preprints and their later publications. For the effects of eight treatments on mortality and mechanical ventilation, the study comprised meta-analyses including preprints and excluding preprints at one, three, and six months after the first trial addressing the treatment became available either as a preprint or publication (120 meta-analyses in total, 60 of which included preprints and 60 of which excluded preprints) and assessed the certainty of evidence using the GRADE framework. RESULTS Of 356 trials included in the study, 101 were only available as preprints, 181 as journal publications, and 74 as preprints first and subsequently published in journals. The median time to publication of preprints was about six months. Key methods and results showed few important differences between trial preprints and their subsequent published reports. Apart from two (3.3%) of 60 comparisons, point estimates were consistent between meta-analyses including preprints versus those excluding preprints as to whether they indicated benefit, no appreciable effect, or harm. For nine (15%) of 60 comparisons, the rating of the certainty of evidence was different when preprints were included versus being excluded-the certainty of evidence including preprints was higher in four comparisons and lower in five comparisons. CONCLUSION No compelling evidence indicates that preprints provide results that are inconsistent with published papers. Preprints remain the only source of findings of many trials for several months-an unsuitable length of time in a health emergency that is not conducive to treating patients with timely evidence. The inclusion of preprints could affect the results of meta-analyses and the certainty of evidence. Evidence users should be encouraged to consider data from preprints.
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页数:14
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