共 117 条
Impact of preterm birth on kidney health and development
被引:10
作者:
Akalay, Sara
[1
,2
]
Rayyan, Maissa
[1
,3
]
Fidlers, Tom
[4
]
van den Heuvel, Lambertus
[1
,5
]
Levtchenko, Elena
[6
]
Arcolino, Fanny Oliveira
[6
,7
]
机构:
[1] Katholieke Univ Leuven, Dept Dev & Regenerat, Leuven, Belgium
[2] Univ Hosp Leuven, Dept Nephrol Dialysis & Renal Transplantat, Leuven, Belgium
[3] Univ Hosp Leuven, Neonatal Intens Care Unit, Leuven, Belgium
[4] Oscar Lambret Canc Ctr, Dept Gynecol Oncol, Lille, France
[5] Radboud Univ Nijmegen, Dept Pediat Nephrol, Med Ctr, Nijmegen, Netherlands
[6] Univ Amsterdam, Emma Childrens Hosp, Dept Pediat Nephrol, Med Ctr, Amsterdam, Netherlands
[7] Univ Amsterdam, Emma Ctr Personalized Med, Med Ctr, Amsterdam, Netherlands
关键词:
preterm birth;
nephrogenesis;
premature infant;
nephron;
chronic kidney disease;
acute kidney injury;
INTRAUTERINE GROWTH RESTRICTION;
GLOMERULAR-FILTRATION-RATE;
YOUNG-ADULT AGE;
NEPHRON NUMBER;
BLOOD-PRESSURE;
IN-UTERO;
WEIGHT;
INFANTS;
DISEASE;
INJURY;
D O I:
10.3389/fmed.2024.1363097
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Preterm birth, defined as birth before the gestational age of 37 weeks, affects 11% of the newborns worldwide. While extensive research has focused on the immediate complications associated with prematurity, emerging evidence suggests a link between prematurity and the development of kidney disease later in life. It has been demonstrated that the normal course of kidney development is interrupted in infants born prematurely, causing an overall decrease in functional nephrons. Yet, the pathogenesis leading to the alterations in kidney development and the subsequent pathophysiological consequences causing kidney disease on the long-term are incompletely understood. In the present review, we discuss the current knowledge on nephrogenesis and how this process is affected in prematurity. We further discuss the epidemiological evidence and experimental data demonstrating the increased risk of kidney disease in these individuals and highlight important knowledge gaps. Importantly, understanding the intricate interplay between prematurity, abnormal kidney development, and the long-term risk of kidney disease is crucial for implementing effective preventive and therapeutic strategies.
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页数:16
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