Enhanced Stability and Solidification of Volatile Eugenol by Cyclodextrin-Metal Organic Framework for Nasal Powder Delivery

被引：0
作者：
Zhu, Huajie [1 ,2 ]
Lv, Yuting [1 ,2 ]
Xin, Fangyuan [2 ,3 ]
Wang, Manli [4 ]
Zhao, Xiangyu [1 ,2 ]
Ren, Xiaohong [5 ]
Zhang, Jiwen [1 ,2 ,3 ,4 ,5 ,6 ]
Yin, Dengke [1 ]
Guo, Tao [5 ]
Wu, Li [1 ,2 ,4 ,5 ,6 ]
机构：
[1] Anhui Univ Chinese Med, Hefei 230000, Anhui, Peoples R China
[2] Yangtze Delta Drug Adv Res Inst, Nantong 226133, Jiangsu, Peoples R China
[3] Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
[4] Jiangxi Univ Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Peoples R China
[5] Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China
[6] Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China
来源：
AAPS PHARMSCITECH | 2024年 / 25卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Eugenol; Cyclodextrin metal-organic framework; Solidification; Nasal powder; Stability; ANTIMICROBIAL ACTIVITY; CHEMICAL-COMPOSITION; THERMAL-STABILITY; BETA-CYCLODEXTRIN; ESSENTIAL OILS; IN-VITRO; CD-MOF; DRUG; BIOAVAILABILITY; TEMPERATURE;
D O I：
10.1208/s12249-024-02839-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Eugenol (Eug) holds potential as a treatment for bacterial rhinosinusitis by nasal powder drug delivery. To stabilization and solidification of volatile Eug, herein, nasal inhalable gamma-cyclodextrin metal-organic framework (gamma-CD-MOF) was investigated as a carrier by gas-solid adsorption method. The results showed that the particle size of Eug loaded by gamma-CD-MOF (Eug@gamma-CD-MOF) distributed in the range of 10-150 mu m well. In comparison to gamma-CD and beta-CD-MOF, gamma-CD-MOF has higher thermal stability to Eug. And the intermolecular interactions between Eug and the carriers were verified by characterizations and molecular docking. Based on the bionic human nasal cavity model, Eug@gamma-CD-MOF had a high deposition distribution (90.07 +/- 1.58%). Compared with free Eug, the retention time Eug@gamma-CD-MOF in the nasal cavity was prolonged from 5 min to 60 min. In addition, the cell viability showed that Eug@gamma-CD-MOF (Eug content range 3.125-200 mu g/mL) was non-cytotoxic. And the encapsulation of gamma-CD-MOF could not reduce the bacteriostatic effect of Eug. Therefore, the biocompatible gamma-CD-MOF could be a potential and valuable carrier for nasal drug delivery to realize solidification and nasal therapeutic effects of volatile oils.
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页数：16
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