Evaluation of feline mesenchymal stem cell susceptibility to feline viruses

被引：1

作者：

Ma, Haoyuan ^{[1
]}

Hao, Jingrui ^{[1
]}

Li, Weijian ^{[1
]}

Yu, Kai ^{[1
]}

Zhu, Kunru ^{[1
]}

Yang, Meng ^{[1
]}

Cao, Shuoning ^{[1
]}

Xue, Haowen ^{[1
]}

Liu, Dan ^{[1
]}

Song, Yanhao ^{[1
]}

Zhang, Siqi ^{[1
]}

Zhang, Xifeng ^{[1
]}

Sun, Zheng ^{[1
]}

Gao, Xu ^{[1
]}

机构：

[1] Yanbian Univ, Coll Agr, Dept Vet Med, Lab Anim Mol Virol, Yanji 133002, Peoples R China

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

关键词：

Feline coronavirus; Feline panleukopenia virus; Feline herpesvirus; Mesenchymal stem cells; CORONAVIRUS; CATS;

D O I：

10.1038/s41598-024-69343-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Feline mesenchymal stem cells (fMSCs) are well known for their robust differentiation capabilities and are commonly used in studying immune-related diseases in cats. Despite their importance, the susceptibility of fMSCs to viral infections remains uncertain. This study aimed to assess the susceptibility of feline adipose-derived mesenchymal stem cells (fAD-MSCs) and feline umbilical cord-derived mesenchymal stem cells (fUC-MSCs) to common feline viruses, including feline coronavirus (FCoV), feline herpesvirus type 1 (FHV-1), and feline panleukopenia virus (FPV). The results demonstrated that both FCoV and FHV-1 were able to infect both types of cells, while FPV did not exhibit cytopathic effects on fUC-MSCs. Furthermore, all three viruses were successfully isolated from fAD-MSCs. These findings suggest that certain feline viruses can replicate in fMSCs, indicating potential limitations in using fMSCs for treating viral diseases caused by these specific viruses. This study has important clinical implications for veterinarians, particularly in the management of viral diseases.

引用

页数：9

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