Seroprevalence of SARS-CoV-2 and Hepatitis B Virus Coinfections among Ethiopians with Acute Leukemia

被引:1
作者
Alemu, Jemal [1 ,2 ,3 ]
Gumi, Balako [3 ]
Tsegaye, Aster [1 ]
Rahimeto, Ziyada [2 ]
Fentahun, Dessalegn [2 ]
Ibrahim, Fozia [2 ]
Abubeker, Abdulaziz [4 ]
Gebremedhin, Amha [4 ]
Gelanew, Tesfaye [2 ]
Howe, Rawleigh [2 ]
机构
[1] Addis Ababa Univ, Coll Hlth Sci, Dept Med Lab Sci, POB 1176, Addis Ababa, Ethiopia
[2] Armauer Hansen Res Inst, POB 1005, Addis Ababa, Ethiopia
[3] Addis Ababa Univ, Aklilu Lemma Inst Pathobiol, POB 1176, Addis Ababa, Ethiopia
[4] Addis Ababa Univ, Coll Hlth Sci, Dept Internal Med, POB 1176, Addis Ababa, Ethiopia
关键词
SARS-CoV-2; blood-borne viruses; acute leukemia; HBV; Ethiopia; INFECTION; COVID-19; CELL;
D O I
10.3390/cancers16081606
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
SARS-CoV-2 and blood-borne viral coinfections are well reported. Nevertheless, little is known regarding the seroprevalence of SARS-CoV-2 and coinfection with blood-borne viruses in hematologic malignancy patients in Ethiopia. We aimed to assess the seroprevalence of SARS-CoV-2 and associated infections with hepatitis B and other viruses among adolescent and adult acute leukemia patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. A cross-sectional study was conducted from July 2020 to June 2021. Blood samples were tested for the presence of anti-SARS-CoV-2, HBV, HCV, and HIV with ELISA kits and occult hepatitis B infection with a real-time polymerase chain reaction assay. Out of a total 110 cases, the SARS-CoV-2 seroprevalence was 35.5%. The prevalence showed a significant increment from July 2020 to the end of June 2021 (p = 0.015). In 22.7% and 2.7% of leukemia cases, HBV and HIV, respectively, were detected. No HCV was identified. The rate of SARS-CoV-2 coinfection with HBV and HIV was 28% (11/39) and 2.6% (1/39), respectively; however, there was no statistically significant association between SARS-CoV-2 seropositivity with HBV and HIV (p > 0.05). There is a need for viral screening in leukemia cases to monitor infections and inform management.
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页数:12
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