The Emerging Role of LPA as an Oncometabolite

被引：2

作者：

Karalis, Theodoros ^{[1
]}

Poulogiannis, George ^{[1
]}

机构：

[1] Inst Canc Res, Div Canc Biol, Signalling & Canc Metab Lab, 237 Fulham Rd, London SW3 6JB, England

来源：

CELLS | 2024年 / 13卷 / 07期

关键词：

lysophosphatidic acid; oncometabolite; phospholipid; cancer metabolism; LYSOPHOSPHATIDIC ACID RECEPTOR; PHOSPHOLIPASE A(2); CELL-MIGRATION; CANCER CELLS; ORPHAN GPCR; AUTOTAXIN; IDENTIFICATION; EXPRESSION; LYSOPHOSPHOLIPASE; ACTIVATION;

D O I：

10.3390/cells13070629

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lysophosphatidic acid (LPA) is a phospholipid that displays potent signalling activities that are regulated in both an autocrine and paracrine manner. It can be found both extra- and intracellularly, where it interacts with different receptors to activate signalling pathways that regulate a plethora of cellular processes, including mitosis, proliferation and migration. LPA metabolism is complex, and its biosynthesis and catabolism are under tight control to ensure proper LPA levels in the body. In cancer patient specimens, LPA levels are frequently higher compared to those of healthy individuals and often correlate with poor responses and more aggressive disease. Accordingly, LPA, through promoting cancer cell migration and invasion, enhances the metastasis and dissemination of tumour cells. In this review, we summarise the role of LPA in the regulation of critical aspects of tumour biology and further discuss the available pre-clinical and clinical evidence regarding the feasibility and efficacy of targeting LPA metabolism for effective anticancer therapy.

引用

页数：20

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