Age and sex differences in the effects of short- and long-term exposure to air pollution on endothelial dysfunction

被引:0
作者
Zhang, Haoyu [1 ]
Yang, Jing [1 ]
Zhang, Yinghua [2 ]
Xiao, Keling [1 ]
Wang, Yang [3 ]
Si, Jin [1 ]
Li, Yan [1 ]
Sun, Lijie [1 ]
Sun, Jinghao [1 ]
Yi, Ming [1 ]
Chu, Xi [4 ]
Li, Jing [1 ]
机构
[1] Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Dept Geriatr, Beijing 100053, Peoples R China
[2] Tsinghua Univ, Dept Neurol, Chuiyangliu Hosp, Beijing 100021, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, Med Res & Biometr Ctr, Natl Ctr Cardiovasc Dis, Fuwai Hosp, Beijing 100037, Peoples R China
[4] Capital Med Univ, Xuanwu Hosp, Hlth Management Ctr, Beijing 100053, Peoples R China
基金
中国国家自然科学基金;
关键词
Air pollution; Endothelial dysfunction; Flow-mediated dilatation; ACUTE MYOCARDIAL-INFARCTION; FLOW-MEDIATED DILATION; CARDIOVASCULAR-DISEASE; ATHEROSCLEROSIS; CHINESE;
D O I
10.1186/s12940-024-01100-3
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background The effects of air pollution on endothelial function remain unclear across populations. We aimed to use brachial artery flow-mediated dilatation (FMD) to identify demographic differences in the effects of air pollution exposure on endothelial dysfunction. Methods We measured FMD in 850 participants from October 2016 to January 2020. Location-specific concentrations of fine particulate matter < 2.5 mu m aerodynamic diameter (PM2.5), inhalable particulate matter < 10 mu m aerodynamic diameter (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O-3) measured by fixed ambient air monitoring stations were collected for short- and long-term exposure assessment. Multiple linear regression models and restricted cubic splines were used to assess the associations before and after stratification by age and sex. Results This study eventually included 828 participants [551 (66.5%) younger than 65 years and 553 (66.8%) men]. Each 10 mu g/m(3) increase in 7-day exposure to PM2.5 and PM10 was significantly linearly associated with a 0.07% (beta = -0.07, 95% CI: -0.13 to -0.004) and 0.05% (beta = -0.05, 95% CI: -0.10 to -0.004) decrease in FMD in the fully adjusted model. After full adjustment, long-term exposure to all air pollutants was significantly associated with impaired FMD. Each 10 mu g/m(3) increase in long-term exposure to PM2.5 and PM10 was significantly associated with a -0.18% (95% CI: -0.34 to -0.03) and - 0.23% (95% CI: -0.40 to -0.06) change in FMD, respectively. After stratification, the associations of lower FMD with long-term exposure to PM2.5, PM10, SO2, NO2, and CO significantly persisted in men and participants younger than 65 years instead of women or older participants. For short-term exposure, we observed differences consistent with long-term exposure and a stronger effect of 7-day exposure to SO2 in men due to a significant interaction effect. Conclusion Short- and long-term exposure to different air pollutants are strongly associated with decreased endothelial function, and susceptibility to air pollution varies significantly with age and sex.
引用
收藏
页数:11
相关论文
共 36 条
[1]   Impact of ambient air pollution on physical activity and sedentary behavior in China: A systematic review [J].
An, Ruopeng ;
Shen, Jing ;
Ying, Binbin ;
Tainio, Marko ;
Andersen, Zorana Jovanovic ;
de Nazelle, Audrey .
ENVIRONMENTAL RESEARCH, 2019, 176
[2]   Endothelial function and chronic exposure to air pollution in normal male subjects [J].
Briet, Marie ;
Collin, Cedric ;
Laurent, Stephane ;
Tan, Alice ;
Azizi, Michel ;
Agharazii, Mohsen ;
Jeunemaitre, Xavier ;
Alhenc-Gelas, Francois ;
Boutouyrie, Pierre .
HYPERTENSION, 2007, 50 (05) :970-976
[3]   Targeting vascular (endothelial) dysfunction [J].
Daiber, Andreas ;
Steven, Sebastian ;
Weber, Alina ;
Shuvaev, Vladimir V. ;
Muzykantov, Vladimir R. ;
Laher, Ismail ;
Li, Huige ;
Lamas, Santiago ;
Muenzel, Thomas .
BRITISH JOURNAL OF PHARMACOLOGY, 2017, 174 (12) :1591-1619
[4]   Obesity and inflammation: the linking mechanism and the complications [J].
Ellulu, Mohammed S. ;
Patimah, Ismail ;
Khaza'ai, Huzwah ;
Rahmat, Asmah ;
Abed, Yehia .
ARCHIVES OF MEDICAL SCIENCE, 2017, 13 (04) :851-863
[5]   The Assessment of Endothelial Function From Research Into Clinical Practice [J].
Flammer, Andreas J. ;
Anderson, Todd ;
Celermajer, David S. ;
Creager, Mark A. ;
Deanfield, John ;
Ganz, Peter ;
Hamburg, Naomi M. ;
Luescher, Thomas F. ;
Shechter, Michael ;
Taddei, Stefano ;
Vita, Joseph A. ;
Lerman, Amir .
CIRCULATION, 2012, 126 (06) :753-767
[6]  
Frampton M W, 2017, Res Rep Health Eff Inst, P1
[7]  
Kim H, 2017, J AM HEART ASSOC, V6, DOI [10.1161/jaha.117.007170, 10.1161/JAHA.117.007170]
[8]   Associations of air pollution, obesity and cardiometabolic health in young adults: The Meta-AIR study [J].
Kim, Jeniffer S. ;
Chen, Zhanghua ;
Alderete, Tanya L. ;
Toledo-Corral, Claudia ;
Lurmann, Fred ;
Berhane, Kiros ;
Gilliland, Frank D. .
ENVIRONMENT INTERNATIONAL, 2019, 133
[9]   Vascular Responses to Long- and Short-Term Exposure to Fine Particulate Matter MESA Air (Multi-Ethnic Study of Atherosclerosisi and Air Pollution) [J].
Krishnan, Ranjini M. ;
Adar, Sara D. ;
Szpiro, Adam A. ;
Jorgensen, Neal W. ;
Van Hee, Victor C. ;
Barr, R. Graham ;
O'Neill, Marie S. ;
Herrington, David M. ;
Polak, Joseph F. ;
Kaufman, Joel D. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 60 (21) :2158-2166
[10]   Cardiovascular and inflammatory mechanisms in healthy humans exposed to air pollution in the vicinity of a steel mill [J].
Kumarathasan, Premkumari ;
Vincent, Renaud ;
Blais, Erica ;
Bielecki, Agnieszka ;
Guenette, Josee ;
Filiatreault, Alain ;
Brion, Orly ;
Cakmak, Sabit ;
Thomson, Errol M. ;
Shutt, Robin ;
Kauri, Lisa Marie ;
Mahmud, Mamun ;
Liu, Ling ;
Dales, Robert .
PARTICLE AND FIBRE TOXICOLOGY, 2018, 15