Correlation of oxidative stress and vascular endothelial dysfunction with hippocampal perfusion in atrial fibrillation patients with cognitive impairment

被引：1
作者：
Ke, Hong Hong [1 ]
Li, Jinyi [2 ]
Liang, Guicheng [1 ]
Li, Shuhu [2 ]
Wang, Shirong [2 ]
Zhong, Guoqiang [1 ,3 ]
机构：
[1] Guangxi Med Univ, Dept Cardiol, Affiliated Hosp 1, Nanning, Guangxi, Peoples R China
[2] Guilin Med Univ, Dept Cardiol, Affiliated Hosp, Guilin, Guangxi, Peoples R China
[3] Guangxi Med Univ, Dept Cardiol, Affiliated Hosp 1, 6 Shuangyong Rd, Nanning 530021, Guangxi, Peoples R China
来源：
SAGE OPEN MEDICINE | 2024年 / 12卷
基金：
中国国家自然科学基金;
关键词：
Oxidative stress; endothelial dysfunction; hippocampal perfusion; atrial fibrillation; cognitive impairment; STROKE; RISK;
D O I：
10.1177/20503121241243247
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives: To evaluate the correlation of oxidative stress and vascular endothelial dysfunction with hippocampal perfusion in patients with atrial fibrillation and cognitive impairment.Methods: In total, 41 atrial fibrillation patients with cognitive impairment were compared to 45 atrial fibrillation patients without cognitive impairment. Oxidative stress, vascular endothelial dysfunction, hippocampal perfusion, and cognitive function were measured.Results: Serum level of oxidized low-density lipoprotein was significantly higher in the atrial fibrillation + cognitive impairment group than in the atrial fibrillation group. Serum levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 were significantly higher, and nitric oxide was lower, in the atrial fibrillation + cognitive impairment group than in the atrial fibrillation group. The regional cerebral blood volume, mean transit time, and time to peak were significantly higher in the atrial fibrillation + cognitive impairment group than in the atrial fibrillation group. Moreover, regional cerebral blood flow was significantly lower in the atrial fibrillation + cognitive impairment group than in the atrial fibrillation group. Age, left atrial diameter, and regional cerebral blood volume were negatively correlated with the cognitive function score in the atrial fibrillation + cognitive impairment group. Serum levels of oxidized low-density lipoprotein, regional cerebral blood volume, regional cerebral blood flow, mean transit time, and time to peak were significantly correlated with cognitive impairment in atrial fibrillation patients after multivariate logistic regression analysis.Conclusion: Hippocampal perfusion and oxidative stress were significantly correlated with cognitive impairment in atrial fibrillation patients.
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页数：6
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