Targeting metabolic-associated fatty liver disease in diabetic kidney disease: A call to action

被引:1
作者
Benlloch, Salvador [1 ,2 ]
Moncho, Francesc [3 ]
Gorriz, Jose Luis [3 ,4 ]
机构
[1] Hosp Arnau Vilanova, Serv Med Digest, Valencia, Spain
[2] Inst Salud Carlos III, CIBERehd, Madrid, Spain
[3] Hosp Clin Univ Valencia, Serv Nefrol, INCLIVA, Valencia, Spain
[4] Univ Valencia, Valencia, Spain
来源
NEFROLOGIA | 2024年 / 44卷 / 02期
关键词
Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Hepatic steatosis; Chronic kidney disease; Liver fibrosis; Type 2 diabetes mellitus; LIFE-STYLE MODIFICATION; SIGNIFICANT FIBROSIS; RISK; NAFLD;
D O I
10.1016/j.nefro.2023.08.005
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Non-alcoholic fatty liver disease or metabolic-associated fatty liver disease (MAFLD) is a common condition with increasing prevalence and incidence, specially in patients with type 2 diabetes mellitus (DM2). Both cardiovascular and renal disease are clearly increased in these patients, particularly in those with diabetic nephropathy. In the liver-heart-kidney-metabolic axis, the common pathophysiological basis of MAFLD, cardiovascular disease (CVD), chronic kidney disease (CKD), and DM2 is the same. The clinical relationship between all of them is clear and is multidirectional: MAFLD may precede the development of cardiovascular and renal disease, and may also worsen the prognosis of these complications once developed. In this review we emphasize the importance of targeting MAFLD in diabetic kidney disease, with the goal of detecting high-risk patients in order (c) 2023 Sociedad Espa & ntilde;ola de Nefrolog & iacute;a. Published by Elsevier Espa & ntilde;a, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/
引用
收藏
页码:129 / 138
页数:10
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